UniProt Accession

 CDD_HUMAN; P32320 

Genbank Protein ID

 L27943; AF061658; AF061655; AF061656; AF061657; AJ000474; AL391357; BC054036; S52873 

Genbank Nucleotide ID

 AAA57254.1; AAD15828.1; AAD15828.1; AAD15828.1; AAD15828.1; CAA04113.1; CAH73474.1; AAH54036.1; AAB24946.1 

Protein Name

 Cytidine deaminase 

Protein Synonyms/Alias

 Cytidine aminohydrolase 

Gene Name

 CDA 

Gene Synonyms/Alias

 CDD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	TQEGRIFKGCNIENA	ubiquitination	[1, 2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. 

Sequence Annotation

 DOMAIN 16 116 CMP/dCMP deaminase zinc-binding.
 REGION 54 60 Substrate binding.
 ACT_SITE 67 67 Proton donor.
 METAL 65 65 Zinc; catalytic.
 METAL 99 99 Zinc; catalytic.
 METAL 102 102 Zinc; catalytic.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Metal-binding; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0005576; C:extracellular region; TAS:UniProtKB.
 GO:0004126; F:cytidine deaminase activity; IDA:UniProtKB.
 GO:0001882; F:nucleoside binding; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0007166; P:cell surface receptor signaling pathway; NAS:UniProtKB.
 GO:0019858; P:cytosine metabolic process; TAS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0045980; P:negative regulation of nucleotide metabolic process; IDA:UniProtKB.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
 GO:0043097; P:pyrimidine nucleoside salvage; TAS:Reactome. 

Interpro

 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR002125; CMP_dCMP_Zn-bd.
 IPR006262; Cyt_deam_tetra.
 IPR016193; Cytidine_deaminase-like. 

Pfam

 PF00383; dCMP_cyt_deam_1 

SMART

  

PROSITE

 PS00903; CYT_DCMP_DEAMINASES 

PRINTS