CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033945
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 High mobility group protein B1 
Protein Synonyms/Alias
  
Gene Name
 Hmgb1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12DPKKPRGKMSSYAFFacetylation[1, 2, 3, 4]
29TCREEHKKKHPDASVacetylation[2]
29TCREEHKKKHPDASVubiquitination[5]
30CREEHKKKHPDASVNacetylation[2, 4]
43VNFSEFSKKCSERWKacetylation[2, 4, 6]
43VNFSEFSKKCSERWKubiquitination[5]
59MSAKEKGKFEDMAKAacetylation[2, 4, 6]
65GKFEDMAKADKARYEacetylation[2]
76ARYEREMKTYIPPKGubiquitination[5]
82MKTYIPPKGETKKKFubiquitination[5]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 92 AA 
Protein Sequence
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF 60
EDMAKADKAR YEREMKTYIP PKGETKKKFK DP 92 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0000793; C:condensed chromosome; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0006288; P:base-excision repair, DNA ligation; IEA:Compara.
 GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Compara.
 GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0043388; P:positive regulation of DNA binding; IEA:Compara.
 GO:0033151; P:V(D)J recombination; IEA:Compara. 
Interpro
 IPR009071; HMG_box_dom.
 IPR017967; HMG_boxA_CS. 
Pfam
 PF09011; DUF1898 
SMART
 SM00398; HMG 
PROSITE
 PS00353; HMG_BOX_1
 PS50118; HMG_BOX_2 
PRINTS