CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prophage DLP12 integrase 
Protein Synonyms/Alias
 Prophage QSR' integrase 
Gene Name
 intD 
Gene Synonyms/Alias
 int; b0537; JW0525 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
296RKMRIDSKTSWLSACacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. 
Sequence Annotation
 ACT_SITE 349 349 O-(3'-phospho-DNA)-tyrosine intermediate  
Keyword
 Complete proteome; DNA integration; DNA recombination; Reference proteome; Viral genome integration; Virus entry into host cell. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MSLFRRNEIW YASYSLPGGK RIKESLGTKD KRQAQELHDK RKAELWRVEK LGDLPDVTFE 60
EACLRWLEEK ADKKSLDSDK SRIEFWLEHF EGIRLKDISE AKIYSAVSRM HNRKTKEIWK 120
QKVQAAIRKG KELPVYEPKP VSTQTKAKHL AMIKAILRAA ERDWKWLEKA PVIKIPAVRN 180
KRVRWLEKEE AKRLIDECPE PLKSVVKFAL ATGLRKSNII NLEWQQIDMQ RRVAWVNPEE 240
SKSNRAIGVA LNDTACKVLR DQIGKHHKWV FVHTKAAKRA DGTSTPAVRK MRIDSKTSWL 300
SACRRAGIED FRFHDLRHTW ASWLIQSGVP LSVLQEMGGW ESIEMVRRYA HLAPNHLTEH 360
ARKIDDIFGD NVPNMSHSEI MEDIKKA 387 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008979; F:prophage integrase activity; ISS:EcoCyc.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. 
Interpro
 IPR011010; DNA_brk_join_enz.
 IPR013762; Integrase-like_cat-core.
 IPR002104; Integrase_catalytic. 
Pfam
 PF00589; Phage_integrase 
SMART
  
PROSITE
  
PRINTS