CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034077
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 2/3 complex subunit 2 
Protein Synonyms/Alias
 MCG114810, isoform CRA_b 
Gene Name
 Arpc2 
Gene Synonyms/Alias
 mCG_114810 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
49SISLKFYKELQAHGAacetylation[1]
49SISLKFYKELQAHGAubiquitination[2]
120FQFQEEGKEGENRAVacetylation[3]
120FQFQEEGKEGENRAVubiquitination[2]
170KVFMQEFKEGRRASHacetylation[3]
259AKTSDFLKVLNRARPacetylation[3]
259AKTSDFLKVLNRARPubiquitination[2]
274DAEKKEMKTITGKTFacetylation[4]
279EMKTITGKTFSSR**ubiquitination[2]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MDVGSHGARN KPEAVEVTFA DFDGVLYHIS NPNGDKTKVM VSISLKFYKE LQAHGADELL 60
KRVYGSFLVN PEPGYNVSLL YDLENLPASK DSIVHQAGML KRNCFASVFE KYFQFQEEGK 120
EGENRAVIHY RDDETMYVES KKDRVTVVFS TVFKDDDDVV IGKVFMQEFK EGRRASHTAP 180
QVLFSHREPP LELKDTDAAV GDNIGYITFV LFPRHTNATA RDNTINLIHT FRDYLHYHIK 240
CSKAYIHTRM RAKTSDFLKV LNRARPDAEK KEMKTITGKT FSSR 284 
Gene Ontology
 GO:0005885; C:Arp2/3 protein complex; TAS:MGI.
 GO:0031252; C:cell leading edge; IDA:MGI.
 GO:0005768; C:endosome; IDA:MGI.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IDA:MGI.
 GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:MGI. 
Interpro
 IPR007188; P34-arc. 
Pfam
 PF04045; P34-Arc 
SMART
  
PROSITE
  
PRINTS