CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interleukin-6 receptor subunit beta 
Protein Synonyms/Alias
 IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130 
Gene Name
 IL6ST 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
649NKRDLIKKHIWPNVPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. 
Sequence Annotation
 DOMAIN 26 120 Ig-like C2-type.
 DOMAIN 125 216 Fibronectin type-III 1.
 DOMAIN 222 321 Fibronectin type-III 2.
 DOMAIN 326 418 Fibronectin type-III 3.
 DOMAIN 423 514 Fibronectin type-III 4.
 DOMAIN 518 610 Fibronectin type-III 5.
 MOTIF 310 314 WSXWS motif.
 MOTIF 651 659 Box 1 motif.
 MOD_RES 667 667 Phosphoserine.
 MOD_RES 782 782 Phosphoserine.
 MOD_RES 829 829 Phosphoserine.
 CARBOHYD 43 43 N-linked (GlcNAc...).
 CARBOHYD 83 83 N-linked (GlcNAc...).
 CARBOHYD 131 131 N-linked (GlcNAc...).
 CARBOHYD 157 157 N-linked (GlcNAc...).
 CARBOHYD 227 227 N-linked (GlcNAc...).
 CARBOHYD 379 379 N-linked (GlcNAc...).
 CARBOHYD 383 383 N-linked (GlcNAc...).
 CARBOHYD 390 390 N-linked (GlcNAc...).
 CARBOHYD 553 553 N-linked (GlcNAc...).
 CARBOHYD 564 564 N-linked (GlcNAc...).
 DISULFID 28 54
 DISULFID 48 103
 DISULFID 134 144
 DISULFID 172 182
 DISULFID 458 466  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 918 AA 
Protein Sequence
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 60
NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 120
ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 180
SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 240
KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 300
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 360
GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL TVRNLVGKSD AAVLTIPACD 420
FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT 480
YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD 540
QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 600
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK 660
SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN 720
TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS 780
ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV 840
NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 900
MPKSYLPQTV RQGGYMPQ 918 
Gene Ontology
 GO:0070110; C:ciliary neurotrophic factor receptor complex; IDA:BHF-UCL.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005896; C:interleukin-6 receptor complex; IDA:BHF-UCL.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005900; C:oncostatin-M receptor complex; IDA:BHF-UCL.
 GO:0004897; F:ciliary neurotrophic factor receptor activity; IDA:BHF-UCL.
 GO:0004921; F:interleukin-11 receptor activity; IEA:Compara.
 GO:0045509; F:interleukin-27 receptor activity; IC:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; TAS:BHF-UCL.
 GO:0005977; P:glycogen metabolic process; IEA:Compara.
 GO:0070102; P:interleukin-6-mediated signaling pathway; IDA:GOC.
 GO:0048861; P:leukemia inhibitory factor signaling pathway; IGI:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; TAS:BHF-UCL.
 GO:0070104; P:negative regulation of interleukin-6-mediated signaling pathway; IDA:BHF-UCL.
 GO:0038165; P:oncostatin-M-mediated signaling pathway; IDA:GOC.
 GO:0002675; P:positive regulation of acute inflammatory response; IC:BHF-UCL.
 GO:0002821; P:positive regulation of adaptive immune response; IC:BHF-UCL.
 GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Compara.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; TAS:BHF-UCL.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0042102; P:positive regulation of T cell proliferation; IMP:BHF-UCL.
 GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IMP:BHF-UCL.
 GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IMP:BHF-UCL.
 GO:0010575; P:positive regulation vascular endothelial growth factor production; TAS:BHF-UCL.
 GO:0008593; P:regulation of Notch signaling pathway; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR003529; Hematopoietin_rcpt_Gp130_CS.
 IPR013783; Ig-like_fold.
 IPR010457; IgC2-like_lig-bd.
 IPR015321; IL6_recept-bd. 
Pfam
 PF00041; fn3
 PF09240; IL6Ra-bind
 PF06328; Lep_receptor_Ig 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3
 PS01353; HEMATOPO_REC_L_F2 
PRINTS