CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001526
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine protease 23 
Protein Synonyms/Alias
 Putative secreted protein Zsig13 
Gene Name
 PRSS23 
Gene Synonyms/Alias
 ZSIG13; UNQ270/PRO307 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50QSTLNLAKPDFGAEAubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 ACT_SITE 175 175 Charge relay system (By similarity).
 ACT_SITE 240 240 Charge relay system (By similarity).
 ACT_SITE 316 316 Charge relay system (By similarity).
 CARBOHYD 93 93 N-linked (GlcNAc...) (Potential).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Potential).
 DISULFID 160 176 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome; Secreted; Serine protease; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 383 AA 
Protein Sequence
MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK PDFGAEAKLE 60
VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYILSSSG DGAQHRDSGS 120
SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF STSVKLSTGC TGTLVAEKHV LTAAHCIHDG 180
KTYVKGTQKL RVGFLKPKFK DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND 240
IGMDYDYALL ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE 300
TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG SPQDFNVAVR 360
ITPLKYAQIC YWIKGNYLDC REG 383 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:LIFEdb.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00089; Trypsin 
SMART
 SM00020; Tryp_SPc 
PROSITE
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS