UniProt Accession

 FPPS_YEAST; P08524; D6VW20; P15495 

Genbank Protein ID

 J05091; Z49442; X05550; BK006943 

Genbank Nucleotide ID

 AAA34606.1; CAA89462.1; CAA29064.1; DAA08636.1 

Protein Name

 Farnesyl pyrophosphate synthase 

Protein Synonyms/Alias

 FPP synthase; FPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase 

Gene Name

 ERG20 

Gene Synonyms/Alias

 BOT3; FDS1; FPP1; YJL167W; J0525 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
52	NYNTPGGKLNRGLSV	ubiquitination	[1]
184	EDKVDLSKFSLKKHS	acetylation	[2]
263	GTDIQDNKCSWVINK	ubiquitination	[1]
289	TLDENYGKKDSVAEA	acetylation	[2]
297	KDSVAEAKCKKIFND	ubiquitination	[1]
300	VAEAKCKKIFNDLKI	acetylation	[2]
325	IAKDLKAKISQVDES	ubiquitination	[1]
336	VDESRGFKADVLTAF	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. 

Sequence Annotation

 METAL 100 100 Magnesium 1 (By similarity).
 METAL 100 100 Magnesium 2 (By similarity).
 METAL 104 104 Magnesium 1 (By similarity).
 METAL 104 104 Magnesium 2 (By similarity).
 METAL 240 240 Magnesium 3 (By similarity).
 BINDING 52 52 Isopentenyl diphosphate (By similarity).
 BINDING 55 55 Isopentenyl diphosphate (By similarity).
 BINDING 93 93 Isopentenyl diphosphate (By similarity).
 BINDING 109 109 Dimethylallyl diphosphate (By
 BINDING 110 110 Isopentenyl diphosphate (By similarity).
 BINDING 197 197 Dimethylallyl diphosphate (By
 BINDING 198 198 Dimethylallyl diphosphate (By
 BINDING 237 237 Dimethylallyl diphosphate (By
 BINDING 254 254 Dimethylallyl diphosphate (By
 BINDING 263 263 Dimethylallyl diphosphate (By  

Keyword

 Complete proteome; Cytoplasm; Isoprene biosynthesis; Lipid biosynthesis; Lipid metabolism; Magnesium; Metal-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 352 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0004161; F:dimethylallyltranstransferase activity; IDA:SGD.
 GO:0004337; F:geranyltranstransferase activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.
 GO:0045337; P:farnesyl diphosphate biosynthetic process; IDA:SGD.
 GO:0033384; P:geranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR000092; Polyprenyl_synt.
 IPR008949; Terpenoid_synth. 

Pfam

 PF00348; polyprenyl_synt 

SMART

  

PROSITE

 PS00723; POLYPRENYL_SYNTHASE_1
 PS00444; POLYPRENYL_SYNTHASE_2 

PRINTS