UniProt Accession

 COASY_MOUSE; Q9DBL7; A2BFA8; Q3TVZ2; Q8K3Y4 

Genbank Protein ID

 AF521095; AK004878; AK159405; AK159912; AK166894; BX255926; BC020046 

Genbank Nucleotide ID

 AAM77669.1; BAB23636.2; BAE35057.1; BAE35475.1; BAE39099.1; CAM24464.1; AAH20046.1 

Protein Name

 Bifunctional coenzyme A synthase 

Protein Synonyms/Alias

 CoA synthase; Phosphopantetheine adenylyltransferase; Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT; Dephospho-CoA kinase; DPCK; Dephosphocoenzyme A kinase; DPCOAK 

Gene Name

 Coasy 

Gene Synonyms/Alias

 Ukr1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
234	DKDLLKSKLLPELLQ	ubiquitination	[1]
306	RFRLENGKEELALYQ	ubiquitination	[1]
416	FGTDILHKDGTINRK	acetylation	[2]
461	EMDVAVAKGKTLCVI	acetylation	[3]
461	EMDVAVAKGKTLCVI	succinylation	[3]
553	KAWNLLQKRLPKAYQ	ubiquitination	[1]
557	LLQKRLPKAYQTRN*	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. 

Sequence Annotation

 DOMAIN 359 562 DPCK.
 NP_BIND 364 371 ATP (Potential).
 REGION 179 357 Phosphopantetheine adenylyltransferase.
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).  

Keyword

 3D-structure; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Kinase; Multifunctional enzyme; Nucleotide-binding; Nucleotidyltransferase; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 563 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004140; F:dephospho-CoA kinase activity; IDA:MGI.
 GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:MGI.
 GO:0015937; P:coenzyme A biosynthetic process; IDA:MGI. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR001977; Depp_CoAkinase.
 IPR027417; P-loop_NTPase.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01121; CoaE
 PF01467; CTP_transf_2 

SMART

  

PROSITE

 PS51219; DPCK 

PRINTS