CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034173
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrin-linked protein kinase 
Protein Synonyms/Alias
  
Gene Name
 Ilk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
85GHRDIVQKLLQYKADacetylation[1]
85GHRDIVQKLLQYKADubiquitination[2]
139YGEMPVDKAKAPLREubiquitination[2]
154LLRERAEKMGQNLNRubiquitination[2]
165NLNRIPYKDTFWKGTubiquitination[2]
170PYKDTFWKGTTRTRPubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 177 AA 
Protein Sequence
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60
NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120
ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRP 177 
Gene Ontology
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0043034; C:costamere; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0043195; C:terminal bouton; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:MGI.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0030030; P:cell projection organization; IMP:MGI.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:MGI.
 GO:0043206; P:extracellular fibril organization; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; ISO:MGI.
 GO:0032288; P:myelin assembly; IEA:Compara.
 GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.
 GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0021675; P:nerve development; IMP:MGI.
 GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IMP:MGI.
 GO:0045773; P:positive regulation of axon extension; IEA:Compara.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Compara.
 GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0045663; P:positive regulation of myoblast differentiation; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IMP:MGI.
 GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Compara.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Compara. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS