CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030345
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinase non-catalytic C-lobe domain (KIND) containing 1 
Protein Synonyms/Alias
  
Gene Name
 Kndc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1180VQFLSLVKKYLQVMYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1742 AA 
Protein Sequence
MQAMDPASRG FYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL SEQEAWAVCL 60
ECSLSMRSVA HAAIFQTLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDLTGNTFE 120
AHIYSLGATL KAALEYVPEP ELEPKLSTDL EGLLSQMQAE DPRERPDLAS IIALCEEKMQ 180
PVSSCRLCRS LSAIGRRVLS IESFGAFQEL SENTWRGRPA PRNVGPKKMP GDLSTDPEAL 240
FPSKGLLQPP ASRDAEQEAG QRPRAPSPKP LLSAPVRNGE NPGQEGLADL VLDARCPLGE 300
LDRDNLRRSR LKKAQTFPRL LQESTETSTL CLSLNGSRNQ LAISEFFPPD PRKLFLEGKN 360
GLSGFKTQSK SRLWPEQEPG VQLDKTPGAG RNPHRSPGAS GQLEASSPSQ GSVEYKPSPS 420
PVDAGDLDHE GHIPRSEEKI PEESRQPGST ATEQSLSLKD LLSKLGRPFR EYELWALCLS 480
CLSTLQTHKE HPAHLCLDNV LVAEDGTVFF GPPPANGAYN SLFLAPEVSE EKLVTEKASV 540
YCVAAVLWTA AKFSVPRDHK LALPRRLKTL LLDMARRHAS ERPSAAEAIK VCSSYLLQRG 600
MDSSKILAHL RASTCKVHPE EETIGLQNAF SVVELKSTTA PAPESSPGFL QVSNDTKLVA 660
VPGPVPGLPP CCKEACELPA AFTSEATHFK PIVLAQDASV TRDQLALPSE SNEKPKEGSG 720
HLDREGTRKQ AALELVEATD LKMSNQLSPG PELQGATPDP DGDSGSPSSA TECSCPHGPV 780
LVTQQKGTSG TPSSPASSLP PEHRPDGEGP LDTTVLPGPT SASQGSRHPC KPPRGKAAAS 840
PSSPRGSDGH PEKPRPADRK LCPSSVDTSS PPKMTACPSL QEAMRLIQEE FAFDGYMDNG 900
LEALIMGEYI YALKDLTFAT FCGAISEKFC DLYWDEQLLK NLFKVVNGPA SPSESTSEEP 960
GSQPEHSPSR CSLSSKRPSL HGLGKEKPAT TWGSGGPCSP TALSDIDSDT LSQGNFEVGF 1020
RSQKSIKVTR EQQPEAEVGG QPGPSQDSTS HASDTVARLA RSEDGGPAGS PGASDFQNCS 1080
PGWSSAFYEA DCFGADVYNY VKDLERQKAN GHTELEAQSP ELEQQLMIEK RNYRKTLKFY 1140
QKLLQKEKRN KGSEVRTMLS KLRGQLDEMK SKVQFLSLVK KYLQVMYAER WGLEPCALPV 1200
IVNIAAAPCD TLDFSPLDES SSLIFYNVNK HPGSGRQKKA RILQAGTPLG LMAYLYSSDA 1260
FLEGYVQQFL YTFRYFCTPH DFLHFLLDRI SSTLSRAHQD PTSTFTKIYR RSLCVLQAWV 1320
EDCYTVDFIR NAGLLGQLED FISSKILPLD GTAEHLLALL EVGTERRADS ASRGADLEDP 1380
KEAEEDTRPF NALCKRFSED GITRKSFSWR LPRGNGLVLP HHKERQYTIA SALPKPCFFE 1440
DFYGPYAKAS EKGPYFLTEY STNQLFTQLT LLQQELFQKC HPVHFLNSRA LGVMDKSAAI 1500
PKASSSESLS AKTCSLFLPN YVQDKYLLQL LRNADDVSTW VAAEIVTSHT SKLQVNLLSK 1560
FLLIAKSCYE QRNFATAMQI LGGLEHLAVR QSPAWRILPA KIAEVMEELK AVEVFLKSDS 1620
LCLMEGRRFR AQPTLPSAHL LAMHIQQLET GGFTMTNGAH RWSKLRNIAK VASQVHAFQE 1680
NPYTFSPDPK LQAHLKQRIA RFSGADVSIL AADNRANFHQ IPGEKHSRKI QDKLRRMKAT 1740
FQ 1742 
Gene Ontology
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
 GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:MGI.
 GO:0021707; P:cerebellar granule cell differentiation; IMP:MGI.
 GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.
 GO:0048814; P:regulation of dendrite morphogenesis; IDA:MGI.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR011019; KIND.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00750; KIND 
PROSITE
 PS51377; KIND
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS