CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031674
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Epithelial cell adhesion molecule 
Protein Synonyms/Alias
  
Gene Name
 EPCAM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196SLRTALQKEITTRYQubiquitination[1, 2]
246DVAYYFEKDVKGESLubiquitination[1]
319VVLVISRKKRMAKYEubiquitination[2]
327KRMAKYEKAEIKEMGubiquitination[1, 2]
331KYEKAEIKEMGEMHRubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
METKHLGRGG AGRAGPHLWR GPRPNCSAGA GGGEPTHSPN SRAVTHQRAP AARECVCENY 60
KLAVNCFVNN NRQCQCTSVG AQNTVICSKL AAKCLVMKAE MNGSKLGRRA KPEGALQNND 120
GLYDPDCDES GLFKAKQCNG TSMCWCVNTA GVRRTDKDTE ITCSERVRTY WIIIELKHKA 180
REKPYDSKSL RTALQKEITT RYQLDPKFIT SILYENNVIT IDLVQNSSQK TQNDVDIADV 240
AYYFEKDVKG ESLFHSKKMD LTVNGEQLDL DPGQTLIYYV DEKAPEFSMQ GLKAGVIAVI 300
VVVVIAVVAG IVVLVISRKK RMAKYEKAEI KEMGEMHREL NA 342 
Gene Ontology
  
Interpro
 IPR000716; Thyroglobulin_1. 
Pfam
 PF00086; Thyroglobulin_1 
SMART
 SM00211; TY 
PROSITE
 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 
PRINTS