UniProt Accession

 DCMC_RAT; Q920F5; Q9WUY2 

Genbank Protein ID

 AJ007704; AF304865; BC061845 

Genbank Nucleotide ID

 CAB46681.1; AAL09352.1; AAH61845.1 

Protein Name

 Malonyl-CoA decarboxylase, mitochondrial 

Protein Synonyms/Alias

 MCD 

Gene Name

 Mlycd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
145	GLFHHISKLDGGVRF	acetylation	[1]
167	LLEAQALKLVEGPHV	acetylation	[1]
312	FLIKRVVKELQKEFP	acetylation	[1]
385	LSSGEWAKSEKLAQA	acetylation	[1]
471	SISYLGSKNIKASEQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. 

Sequence Annotation

 REGION 298 304 Malonyl-CoA binding (By similarity).
 MOTIF 490 492 Microbody targeting signal (Potential).
 BINDING 328 328 Malonyl-CoA (By similarity).
 BINDING 422 422 Malonyl-CoA (By similarity).
 DISULFID 205 205 Interchain (Potential).  

Keyword

 Alternative initiation; Complete proteome; Cytoplasm; Decarboxylase; Direct protein sequencing; Disulfide bond; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Lyase; Mitochondrion; Peroxisome; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005777; C:peroxisome; IDA:RGD.
 GO:0050080; F:malonyl-CoA decarboxylase activity; IDA:RGD.
 GO:0006085; P:acetyl-CoA biosynthetic process; IDA:RGD.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0019395; P:fatty acid oxidation; IDA:RGD.
 GO:2001294; P:malonyl-CoA catabolic process; IEA:Compara.
 GO:0046321; P:positive regulation of fatty acid oxidation; IEA:Compara.
 GO:0031998; P:regulation of fatty acid beta-oxidation; IDA:RGD.
 GO:0010906; P:regulation of glucose metabolic process; IEA:Compara. 

Interpro

 IPR007956; Malonyl_CoA_deC. 

Pfam

 PF05292; MCD 

SMART

  

PROSITE

  

PRINTS