CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031960
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch-like protein 22 
Protein Synonyms/Alias
 cDNA FLJ53985, highly similar to Kelch-like protein 22 
Gene Name
 KLHL22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52YRQLPLEKVYSLLSSubiquitination[1]
117VLQRLHDKLDPSPLRubiquitination[1]
176TVLSDQAKYLNPLLGubiquitination[1]
186NPLLGEWKHFTASLAubiquitination[1]
290WAYVAPLKREVYAHAubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kelch repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MSWVDEENIL DVYRLAELFD LSRLTEQLDT YILKNFVAFS RTDKYRQLPL EKVYSLLSSN 60
RLEVSCETEV YEGALLYHYS LEQVQADQIS LHEPPKLLET VRFPLMEAEV LQRLHDKLDP 120
SPLRDTVASA LMYHRNESLQ PSLQSPQTEL RSDFQCVVGF GGIHSTPSTV LSDQAKYLNP 180
LLGEWKHFTA SLAPRMSNQG IAVLNNFVYL IGGDNNVQGF RAESRCWRYD PRHNRWFQIQ 240
SLQQEHADLS VCVVGRYIYA VAGRDYHNDL NAVERYDPAT NSWAYVAPLK REVYAHAGAT 300
LEGKMYITCG RRGEDYLKET HCYDPGSNTW HTLADGPVRR AWHGMATLLN KLYVIGGSNN 360
DAGYRRDVHQ VACYSCTSGQ WSSVCPLPAG HGEPGIAVLD NRIYVLGGRS HNRGSRTGYV 420
HIYDVEKDCW EEGPQLDNSI SGLAACVLTL PRSLLLEPPR GTPDRSQADP DFASEVMSVS 480
DWEEFDNSSE D 491 
Gene Ontology
  
Interpro
 IPR011705; BACK.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF07707; BACK
 PF01344; Kelch_1 
SMART
 SM00875; BACK
 SM00612; Kelch 
PROSITE
  
PRINTS