CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016644
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PX domain-containing protein kinase-like protein 
Protein Synonyms/Alias
 Modulator of Na,K-ATPase; MONaKA 
Gene Name
 Pxk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
256KKYCNPKKTQGLELQubiquitination[1]
266GLELQQIKTYGRQILubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. 
Sequence Annotation
 DOMAIN 14 126 PX.
 DOMAIN 88 481 Protein kinase.
 DOMAIN 548 567 WH2.  
Keyword
 Actin-binding; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 582 AA 
Protein Sequence
MAFMEKPPAG KVLLDDTVPL TAAVEASQSL QSHTEYIIRV QRGISAENSW QIVRRYSDFD 60
LLNNSLQITG LSLPLPPKKL IGNMDREFIA ERQRGLQNYL NVIMANHVLS NCELLKKFLD 120
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW 180
ADLGPDKYLS DKDFQCLIKL LPSCVHPYIY RVTFATASES SALLIRAFNE KGTLKDLIYK 240
AKPKDPFLKK YCNPKKTQGL ELQQIKTYGR QILEALKFLH DKGFPYGHLH AANVMLDGNT 300
CRLLDLENSL LGLPSFYRSY FTQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP 360
PASSLAVVAV LESTLSCEAC KNGMPTVSRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR 420
IAKECIEKRL TEEQKQIHQH RRLTRAQSHH GSEEERKRRK ILARKKSKRS AVENSEEQPV 480
KHSNSNNSAG SGASSPLTSP SSPTPPSTAG LSSALPPPPP PPPPPPPPAG PSPTSATEMP 540
APFLPQPVNG VNRGALLSSI QNFQKGTLRK AQTCDHSAPK IG 582 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0032780; P:negative regulation of ATPase activity; IDA:UniProtKB.
 GO:0043271; P:negative regulation of ion transport; IDA:UniProtKB.
 GO:0050804; P:regulation of synaptic transmission; IEP:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR001683; Phox.
 IPR000719; Prot_kinase_cat_dom.
 IPR003124; WH2_dom. 
Pfam
 PF00069; Pkinase
 PF00787; PX
 PF02205; WH2 
SMART
 SM00312; PX 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS50195; PX
 PS51082; WH2 
PRINTS