CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038618
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytosolic purine 5'-nucleotidase 
Protein Synonyms/Alias
  
Gene Name
 Nt5c2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
237AVDWVHYKGSLKEKTacetylation[1]
318LILVDARKPLFFGEGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
 ACT_SITE 78 78 Nucleophile (By similarity).
 ACT_SITE 80 80 Proton donor (By similarity).
 METAL 78 78 Magnesium (By similarity).
 METAL 80 80 Magnesium; via carbonyl oxygen (By
 METAL 377 377 Magnesium (By similarity).  
Keyword
 Complete proteome; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 586 AA 
Protein Sequence
MVPGSGPGAR LRRDLARTRR IHPTNKMTTS WSDRLQNAAD VPANMDKHAL KKYRREAYHR 60
VFVNRSLAME KIKCFGFDMD YTLAVYKSPE YESLGFELTV ERLVSIGYPQ ELLSFAYDST 120
FPTRGLVFDT LYGNLLKVDA YGNLLVCAHG FNFIRGPETR EQYPNKFIQR DDTERFYILN 180
TLFNLPETYL LACLVDFFTN CPRYTSCDTG FKDGDLFMSY RSMFQDVRDA VDWVHYKGSL 240
KEKTVENLEK YVVKDGKLPL LLSRMKEVGK VFLATNSDYK YTDKIMTYLF DFPHGPKPGS 300
SHRPWQSYFD LILVDARKPL FFGEGTVLRQ VDTKTGKLKI GTYTGPLQHG IVYSGGSSDT 360
ICDLLGAKGK DILYIGDHIF GDILKSKKRQ GWRTFLVIPE LAQELHVWTD KSSLFEELQS 420
LDIFLAELYK HLDSSSNERP DISSIQRRIK KVTHDMDMCY GMMGSLFRSG SRQTLFASQV 480
MRYADLYAAS FINLLYYPFS YLFRAAHVLM PHESTVEHTH VDINEMESPL ATRNRTSVDF 540
KDTDYKRHQL TRSISEIKPP NLFPLAPQEI THCHDEDDDE EEEEEE 586 
Gene Ontology
 GO:0008253; F:5'-nucleotidase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR023214; HAD-like_dom.
 IPR008380; HAD-SF_hydro_IG_5-nucl.
 IPR016695; Pur_nucleotidase. 
Pfam
 PF05761; 5_nucleotid 
SMART
  
PROSITE
  
PRINTS