| Tag | Content |
|---|
| CPLM ID | CPLM-013297 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription elongation factor A protein 1 |
Protein Synonyms/Alias | Transcription elongation factor S-II protein 1 |
Gene Name | Tcea1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 67 | EEVTSLAKSLIKSWK | acetylation | [1] | | 71 | SLAKSLIKSWKKLLD | acetylation | [1] | | 75 | SLIKSWKKLLDGPST | acetylation | [1] | | 84 | LDGPSTDKDSEEKKK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). |
Sequence Annotation | DOMAIN 3 80 TFIIS N-terminal.
DOMAIN 140 256 TFIIS central.
ZN_FING 259 299 TFIIS-type.
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 97 97 Phosphoserine (By similarity).
MOD_RES 100 100 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 301 AA |
Protein Sequence | MEDEVVRIAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV NAIRKQSTDE 60
EVTSLAKSLI KSWKKLLDGP STDKDSEEKK KEPAISSQNS PEAREESSSS SHVSSRKDET 120
NARDTYVSSF PRAPSTSDSV RLKCREMLAA ALRTGDDYVA IGADEEELGS QIEEAIYQEI 180
RNTDMKYKNR VRSRISNLKD AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL 240
TKEAIREHQM AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF 300
C 301 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0032784; P:regulation of DNA-dependent transcription, elongation; IEA:InterPro. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |