UniProt Accession

 VATH_MOUSE; Q8BVE3; Q921X8 

Genbank Protein ID

 AK078767; BC009154 

Genbank Nucleotide ID

 BAC37382.1; AAH09154.1 

Protein Name

 V-type proton ATPase subunit H 

Protein Synonyms/Alias

 V-ATPase subunit H; Vacuolar proton pump subunit H 

Gene Name

 Atp6v1h 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
325	LENLEQQKYDDEDIS	ubiquitination	[1, 2]
371	LEWSPVHKSEKFWRE	acetylation	[3]
374	SPVHKSEKFWRENAV	acetylation	[3]
386	NAVRLNEKNYELLKI	acetylation	[3]
392	EKNYELLKILTKLLE	acetylation	[3]
392	EKNYELLKILTKLLE	ubiquitination	[1]
396	ELLKILTKLLEVSDD	ubiquitination	[1]
469	HNWEYLGKQLQSEQP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). 

Sequence Annotation

 MOD_RES 483 483 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 483 AA 

Protein Sequence

Gene Ontology

 GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0006897; P:endocytosis; IEA:Compara. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR004908; ATPase_V1-cplx_hsu.
 IPR011987; ATPase_V1-cplx_hsu_C. 

Pfam

 PF11698; V-ATPase_H_C
 PF03224; V-ATPase_H_N 

SMART

  

PROSITE

  

PRINTS