CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low affinity vacuolar monovalent cation/H(+) antiporter 
Protein Synonyms/Alias
 Vacuolar Na(+)/H(+) exchanger 
Gene Name
 VNX1 
Gene Synonyms/Alias
 YNL321W; N0339 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
3*****MAKNNHISASubiquitination[1]
21TSGDHRLKEEVLTPTubiquitination[1, 2]
123TATPSSPKRMHSSIRubiquitination[2]
Reference
 [1] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Has a role in promoting intracellular monovalent cation sequestration via the exchange of monovalent cations and especially Na(+) for hydrogen ions across the vacuolar membrane. 
Sequence Annotation
 MOD_RES 26 26 Phosphothreonine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 33 33 Phosphothreonine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 118 118 Phosphothreonine.
 MOD_RES 121 121 Phosphoserine.
 CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 908 AA 
Protein Sequence
MAKNNHISAS GNSTSGDHRL KEEVLTPTTS ASTPHRIFSV DDDPKEIQND IRYLEGLHEG 60
LKFALHANKS KRSVSSQSPI VHSSNNTLHH HEHQQHLPPT LESLSSKSHS VPDLNTATPS 120
SPKRMHSSIR ELPHDDNDDE DANDDSRFII HDSHGHDLLI DEINCQSPSH LENNDQASNA 180
SSTESFTLRE RQDAINETHP FGIRIWKPAL YKKHRSVQRT AAQDIHETQL KTITWEVTCS 240
NVLWFILFGF PIAILFYSAA IVVFLLGGGG LVTNSAKEYS KCLYKLANYF LWPFGKMVYL 300
LQDEQYLQED KDEGISMQQF YNWVTSYSNR LVFHQSQAKF QQREDHPAPA TESSSLMPPA 360
NTTATPLNSN HPSYNSIRHE IPHAAAQRRY FGRGKWSWGR VLFYTIFHLV LQPILAVLSL 420
CLWLLVFTIP MSNVLWQIMY HCRRHPLALG FKYVENSSQS HENEITQQQL NKNILLCTFR 480
AAGWHYYKYT VDGTNVIVVN LISIVFFTIF DFYVLKNFLH WKTWFTYESS IFILCLTSTI 540
PLAFYIGQAV ASISAQTSMG VGAVINAFFS TIVEIFLYCV ALQQKKGLLV EGSMIGSILG 600
AVLLLPGLSM CGGALNRKTQ RYNPASAGVS SALLIFSMIV MFVPTVLYEI YGGYSVNCAD 660
GANDRDCTFS HPPLKFNRLF THVIQPMSIS CAIVLFCAYI IGLWFTLRTH AKMIWQLPIA 720
DPTSTAPEQQ EQNSHDAPNW SRSKSTCILL MSTLLYAIIA EILVSCVDAV LEDIPSLNPK 780
FLGLTIFALI PNTTEFLNAI SFAIHGNVAL SMEIGSAYAL QVCLLQIPSL VIYSIFYTWN 840
VKKSMINIRT QMFPLVFPRW DIFGAMTSVF MFTYLYAEGK SNYFKGSMLI LLYIIIVVGF 900
YFQGALSE 908 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0015369; F:calcium:hydrogen antiporter activity; IMP:SGD.
 GO:0015386; F:potassium:hydrogen antiporter activity; IMP:SGD.
 GO:0015385; F:sodium:hydrogen antiporter activity; IMP:SGD. 
Interpro
 IPR005185; DUF307.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03733; DUF307
 PF01699; Na_Ca_ex 
SMART
  
PROSITE
  
PRINTS