| Tag | Content |
|---|
| CPLM ID | CPLM-017845 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cell division cycle protein 16 homolog |
Protein Synonyms/Alias | Anaphase-promoting complex subunit 6; APC6; Cyclosome subunit 6 |
Gene Name | Cdc16 |
Gene Synonyms/Alias | Anapc6 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 431 | WFLDALEKIKAIGNE | ubiquitination | [1] | | 543 | ADIKDKLKCYDFDVH | ubiquitination | [1] | | 553 | DFDVHTMKTLKNIIS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
Sequence Annotation | REPEAT 130 163 TPR 1.
REPEAT 299 333 TPR 2.
REPEAT 334 367 TPR 3.
REPEAT 369 401 TPR 4.
REPEAT 403 435 TPR 5.
REPEAT 445 478 TPR 6.
REPEAT 479 512 TPR 7.
MOD_RES 490 490 Phosphoserine (By similarity).
MOD_RES 560 560 Phosphoserine (By similarity).
MOD_RES 599 599 Phosphothreonine (By similarity). |
Keyword | Cell cycle; Cell division; Complete proteome; Mitosis; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 620 AA |
Protein Sequence | MNLEPLRKRV RQYLDQQQYQ SALFWADKVA SLSHEEPQDV YWLAQCLYLT AQYHRAAHAL 60
RSRKLDKLYE ACRYLAARCH YAAKEHQQAL DILDMEEPIN RRLFEKYLKD DNGSRDPSSD 120
WEMSQSSIKS SICLLRGKIY DALDNRTLAT YSYKEALKLD VYCFEAFDLL TSHHMLTAQE 180
EKELLDSLPL NKLCAEEQEL LRFVFENKLK KYNKPSETVI PESVDGLQEN LDVVVSLAER 240
HYYNCDFKMC YKLTSTVMEK DPFHANCLPV HIGTLVELNK ANELFYLSHK LVDLYPSNPV 300
SWFAVGCYYL MVGHKNEHAR RYLSKATTLE KTYGPAWIAY GHSFAVESEH DQAMAAYFTA 360
AQLMKGCHLP MLYIGLEYGL TNNSKLAERF FGQALSIAPE DPFVIHEVGV VAFQNGEWKT 420
AEKWFLDALE KIKAIGNEVT VDKWEPLLNN LGHVCRKLKK YAEALDYHRQ ALVLIPQNAS 480
TYSAIGYIHS LMGNFENAVD YFHTALGLRR DDTFSVTMLG HCIEMYIGDS EAYIGADIKD 540
KLKCYDFDVH TMKTLKNIIS PPWDFRDFEV EKQNTEEAGL APLQNSTKAP ESRPNLEETF 600
EIEMNESDMM LETSMSDHST 620 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |