UniProt Accession

 SPF30_RAT; Q4QQU6; Q4KM88 

Genbank Protein ID

 BC097986; BC098697 

Genbank Nucleotide ID

 AAH97986.1; AAH98697.1 

Protein Name

 Survival of motor neuron-related-splicing factor 30 

Protein Synonyms/Alias

 Survival motor neuron domain-containing protein 1 

Gene Name

 Smndc1 

Gene Synonyms/Alias

 Spf30 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
7	*MSEDLAKQLASYKA	acetylation	[1]
219	GTCGIADKPMTQYQD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Necessary for spliceosome assembly. Overexpression causes apoptosis (By similarity). 

Sequence Annotation

 DOMAIN 72 132 Tudor.
 MOTIF 142 160 Nuclear localization signal (Potential).
 MOD_RES 201 201 Phosphoserine (By similarity).
 MOD_RES 219 219 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Apoptosis; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR010304; Survival_motor_neuron.
 IPR002999; Tudor. 

Pfam

 PF06003; SMN 

SMART

 SM00333; TUDOR 

PROSITE

 PS50304; TUDOR 

PRINTS