CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015087
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol polyphosphate 5-phosphatase OCRL-1 
Protein Synonyms/Alias
  
Gene Name
 Ocrl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
448NELHKLLKFDQLNIQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (By similarity). 
Sequence Annotation
 DOMAIN 1 119 PH.
 DOMAIN 720 900 Rho-GAP.
 REGION 236 562 5-phosphatase (By similarity).
 REGION 563 677 ASH (By similarity).
 MOTIF 73 77 Clathrin box 1.
 MOTIF 701 705 Clathrin box 2.  
Keyword
 Alternative splicing; Cell projection; Cilium; Cilium biogenesis/degradation; Coated pit; Complete proteome; Cytoplasmic vesicle; Endosome; Golgi apparatus; Hydrolase; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 900 AA 
Protein Sequence
MEPRLPIGAQ PLAMVAGLEM KGPLREPCVL TLARRNGQYE LIIQLHGKEQ HVQDIIPINS 60
HFRCVQEAEE TLLIDIASNS GCKIRVQGDW TRERHFEIPD EERCLKFLSE VLEAQEAQSQ 120
LLVPEQKDSS SWYQKLDTMD KPAYSGLLGF EDNFSSLDLD KKMNTQNPRS GSHREPPPPP 180
SSSTRMLSRE KEASNKEQPK VTNTMRKLFV PNTQTGQREG LIKHILTKRE KEYVNIQSFR 240
FFVGTWNVNG QSPDSSLEPW LDCDPNPPDI YCIGFQELDL STEAFFYFES VKEQEWSLAV 300
ERGLPSKAKY RKVQLVRLVG MMLLIFARKD QCQYIRDVAT ETTGTGIMGK MGNKGGVAVR 360
FVFHNTTFCI VNSHLAAHVE EFERRNQDYK DICARMTFSV PNQTVPQVNI MKHDVVIWLG 420
DLNYRLCMPD ASEVKSLINK NELHKLLKFD QLNIQRTQKK AFADFNEGEI NFVPTYKYDS 480
KTDRWDSSGK CRVPAWCDRI LWRGINVNQL HYRSHMELKT SDHKPVSALF HIGVKVVDER 540
RYRKVFEDIV RIMDRMENDF LPSLELSRRE FFFENVKFRQ LQKEKFQISN NGQVPCHFSF 600
IPKLNDSQYC KPWLRAEPFE GYLEPNETLD ISLDVYVSKD SVTILNSGED KIEDILVLHL 660
DRGKDYFLTI GGNYLPSCFG TSLEALCRMK RPIREVPVTK LIDLEEDSYL EKEKSLLQMV 720
PLDEGTSERP LQVPKEIWLL VDHLFKYACH QEDLFQTPGM QEELQQIIDC LDTSIPETIP 780
GNNHSVAEAL LIFLEALPEP VICYELYQRC LDSAHDPRIC KQVISQLPRC HRNVFRYLMA 840
FLRELLKFSD YNNINTNMIA TLFSSLLLRP PPNLMTRQTP NDRQHAIQFL LVFLLGNEED 900 
Gene Ontology
 GO:0030136; C:clathrin-coated vesicle; IEA:Compara.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; ISS:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:MGI.
 GO:0030675; F:Rac GTPase activator activity; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.
 GO:0032314; P:regulation of Rac GTPase activity; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF03372; Exo_endo_phos
 PF00620; RhoGAP 
SMART
 SM00128; IPPc
 SM00324; RhoGAP 
PROSITE
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS