CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003766
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myoblast determination protein 1 
Protein Synonyms/Alias
  
Gene Name
 Myod1 
Gene Synonyms/Alias
 Myod 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99RCLLWACKACKRKTTacetylation[1, 2]
102LWACKACKRKTTNADacetylation[1, 2]
104ACKACKRKTTNADRRacetylation[1]
Reference
 [1] Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.
 Sartorelli V, Puri PL, Hamamori Y, Ogryzko V, Chung G, Nakatani Y, Wang JY, Kedes L.
 Mol Cell. 1999 Nov;4(5):725-34. [PMID: 10619020]
 [2] CREB-binding protein/p300 activates MyoD by acetylation.
 Polesskaya A, Duquet A, Naguibneva I, Weise C, Vervisch A, Bengal E, Hucho F, Robin P, Harel-Bellan A.
 J Biol Chem. 2000 Nov 3;275(44):34359-64. [PMID: 10944526] 
Functional Description
 Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. 
Sequence Annotation
 DOMAIN 109 160 bHLH.
 CROSSLNK 1 1 Peptide (Met-Gly) (interchain with G-Cter  
Keyword
 3D-structure; Acetylation; Complete proteome; Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 318 AA 
Protein Sequence
MELLSPPLRD IDLTGPDGSL CSFETADDFY DDPCFDSPDL RFFEDLDPRL VHMGALLKPE 60
EHAHFPTAVH PGPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR 120
RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAFYAP 180
GPLPPGRGSE HYSGDSDASS PRSNCSDGMM DYSGPPSGPR RQNGYDTAYY SEAARESRPG 240
KSAAVSSLDC LSSIVERIST DSPAAPALLL ADAPPESPPG PPEGASLSDT EQGTQTPSPD 300
AAPQCPAGSN PNAIYQVL 318 
Gene Ontology
 GO:0030016; C:myofibril; IDA:MGI.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005667; C:transcription factor complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; TAS:MGI.
 GO:0055007; P:cardiac muscle cell differentiation; NAS:UniProtKB.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IDA:MGI.
 GO:0071453; P:cellular response to oxygen levels; IDA:MGI.
 GO:0009267; P:cellular response to starvation; IDA:MGI.
 GO:0007518; P:myoblast fate determination; IDA:MGI.
 GO:0014904; P:myotube cell development; IEA:Compara.
 GO:0014908; P:myotube differentiation involved in skeletal muscle regeneration; IMP:MGI.
 GO:0051149; P:positive regulation of muscle cell differentiation; IEA:Compara.
 GO:1901741; P:positive regulation of myoblast fusion; IEA:Compara.
 GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IDA:MGI.
 GO:0043503; P:skeletal muscle fiber adaptation; IMP:MGI.
 GO:0048741; P:skeletal muscle fiber development; IMP:MGI. 
Interpro
 IPR002546; Basic.
 IPR011598; bHLH_dom.
 IPR022032; Myf5. 
Pfam
 PF01586; Basic
 PF00010; HLH
 PF12232; Myf5 
SMART
 SM00520; BASIC
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS