Tag | Content |
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CPLM ID | CPLM-000841 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Contactin-associated protein 1 |
Protein Synonyms/Alias | Caspr; Caspr1; MHDNIV; NCP1; Neurexin IV; Neurexin-4; Paranodin |
Gene Name | Cntnap1 |
Gene Synonyms/Alias | Nrxn4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1332 | HDSHPGGKAPLPPSG | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Mice that lack CNTAP1 exhibit tremor, ataxia, and significant motor paresis. Normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and potassium channels are displaced from the juxtaparanodal into the paranodal domains. Also results in a severe decrease in peripheral nerve conduction velocity. |
Sequence Annotation | DOMAIN 26 169 F5/8 type C. DOMAIN 204 356 Laminin G-like 1. DOMAIN 390 539 Laminin G-like 2. DOMAIN 545 577 EGF-like 1. DOMAIN 577 796 Fibrinogen C-terminal. DOMAIN 814 958 Laminin G-like 3. DOMAIN 962 996 EGF-like 2. DOMAIN 1089 1251 Laminin G-like 4. MOTIF 1334 1370 SH3-binding (Potential). MOD_RES 1384 1384 Phosphoserine. CARBOHYD 121 121 N-linked (GlcNAc...) (Potential). CARBOHYD 129 129 N-linked (GlcNAc...) (Potential). CARBOHYD 277 277 N-linked (GlcNAc...) (Potential). CARBOHYD 421 421 N-linked (GlcNAc...) (Potential). CARBOHYD 500 500 N-linked (GlcNAc...) (Potential). CARBOHYD 519 519 N-linked (GlcNAc...) (Potential). CARBOHYD 598 598 N-linked (GlcNAc...) (Potential). CARBOHYD 654 654 N-linked (GlcNAc...) (Potential). CARBOHYD 665 665 N-linked (GlcNAc...) (Potential). CARBOHYD 764 764 N-linked (GlcNAc...) (Potential). CARBOHYD 805 805 N-linked (GlcNAc...) (Potential). CARBOHYD 844 844 N-linked (GlcNAc...) (Potential). CARBOHYD 861 861 N-linked (GlcNAc...) (Potential). CARBOHYD 949 949 N-linked (GlcNAc...) (Potential). CARBOHYD 957 957 N-linked (GlcNAc...) (Potential). CARBOHYD 1079 1079 N-linked (GlcNAc...) (Potential). CARBOHYD 1148 1148 N-linked (GlcNAc...) (Potential). DISULFID 26 169 By similarity. DISULFID 324 356 By similarity. DISULFID 507 539 By similarity. DISULFID 545 556 By similarity. DISULFID 550 565 By similarity. DISULFID 567 577 By similarity. DISULFID 931 958 By similarity. DISULFID 962 975 By similarity. DISULFID 969 984 By similarity. DISULFID 986 996 By similarity. DISULFID 1210 1251 By similarity. |
Keyword | Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; SH3-binding; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1385 AA |
Protein Sequence | MMSLRLFSIL LATVVSGAWG WGYYGCNEEL VGPLYARSLG ASSYYGLFTT ARFARLHGIS 60 GWSPRIGDPN PWLQIDLMKK HRIRAVATQG AFNSWDWVTR YMLLYGDRVD SWTPFYQKGH 120 NATFFGNVND SAVVRHDLHY HFTARYIRIV PLAWNPRGKI GLRLGIYGCP YTSSILYFDG 180 DDAISYRFQR GASQSLWDVF AFSFKTEEKD GLLLHTEGSQ GDYVTLELQG AHLLLHMSLG 240 SSPIQPRPGH TTVSLGGVLN DLSWHYVRVD RYGRDANFTL DGYAHHFVLN GDFERLNLEN 300 EIFIGGLVGA ARKNLAYRHN FRGCIENVIY NRINIAEMAV MRHSRITFEG NVAFRCLDPV 360 PHPINFGGPH NFVQVPGFPR RGRLAVSFRF RTWDLTGLLL FSHLGDGLGH VELMLSEGQV 420 NVSIAQTGRK KLQFAAGYRL NDGFWHEVNF VAQENHAVIS IDDVEGAEVR VSYPLLIRTG 480 TSYFFGGCPK PASRWGCHSN QTAFHGCMEL LKVDGQLVNL TLVEFRKLGY FAEVLFDTCG 540 ITDRCSPNMC EHDGRCYQSW DDFICYCELT GYKGVTCHEP LYKESCEAYR LSGKYSGNYT 600 IDPDGSGPLK PFVVYCDIRE NRAWTVVRHD RLWTTRVTGS SMDRPFLGAI QYWNASWEEV 660 SALANASQHC EQWIEFSCYN SRLLNTAGGY PYSFWIGRNE EQHFYWGGSQ PGIQRCACGL 720 DQSCVDPALH CNCDADQPQW RTDKGLLTFV DHLPVTQVVV GDTNRSNSEA QFFLRPLRCY 780 GDRNSWNTIS FHTGAALRFP PIRANHSLDV SFYFRTSAPS GVFLENMGGP FCRWRRPYVR 840 VELNTSRDVV FAFDIGNGDE NLTVHSDDFE FNDDEWHLVR AEINVKQARL RVDHRPWVLR 900 PMPLQTYIWL VYDQPLYVGS AELKRRPFVG CLRAMRLNGV TLNLEGRANA SEGTFPNCTG 960 HCTHPRFPCF HGGRCVERYS YYTCDCDLTA FDGPYCNHDI GGFFETGTWM RYNLQSALRS 1020 AAREFSHMLS RPVPGYEPGY VPGYDTPGYV PGYHGPGYRL PEYPRPGRPV PGYRGPVYNV 1080 TGEEVSFSFS TNSAPAVLLY VSSFVRDYMA VLIKEDGTLQ LRYQLGTSPY VYQLTTRPVT 1140 DGQPHSVNIT RVYRNLFIQV DYFPLTEQKF SLLVDSQLDS PKALYLGRVM ETGVIDPEIQ 1200 RYNTPGFSGC LSGVRFNNVA PLKTHFRTPR PMTAELAEAM RVQGELSESN CGAMPRLVSE 1260 VPPELDPWYL PPDFPYYHDD GWIAILLGFL VAFLLLGLVG MLVLFYLQNH RYKGSYHTNE 1320 PKATHDSHPG GKAPLPPSGP AQAPAPTPAP TQLPTPAPAP APAPASGPGP RDQNLPQILE 1380 ESRSE 1385 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0033270; C:paranode region of axon; IDA:BHF-UCL. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0008088; P:axon cargo transport; IMP:BHF-UCL. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0007010; P:cytoskeleton organization; IMP:BHF-UCL. GO:0050885; P:neuromuscular process controlling balance; IMP:BHF-UCL. GO:0050884; P:neuromuscular process controlling posture; IMP:BHF-UCL. GO:0048812; P:neuron projection morphogenesis; IMP:BHF-UCL. GO:0030913; P:paranodal junction assembly; IMP:BHF-UCL. GO:0002175; P:protein localization to paranode region of axon; IMP:BHF-UCL. |
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