CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome biogenesis protein ENP2 
Protein Synonyms/Alias
 Essential nuclear protein 2 
Gene Name
 ENP2 
Gene Synonyms/Alias
 YGR145W; G6623 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
31SLPDWIAKKRKRQLKacetylation[1]
38KKRKRQLKNDLEYQNacetylation[1]
463VNKTLVDKLSQKRGDacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 May be involved in rRNA-processing and ribosome biosynthesis. 
Sequence Annotation
 REPEAT 54 94 WD 1.
 REPEAT 178 217 WD 2.
 REPEAT 226 265 WD 3.
 REPEAT 269 310 WD 4.
 REPEAT 312 351 WD 5.
 MOD_RES 529 529 Phosphoserine.
 MOD_RES 550 550 Phosphoserine.
 MOD_RES 555 555 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 707 AA 
Protein Sequence
MVLKSTSAND VSVYQVSGTN VSRSLPDWIA KKRKRQLKND LEYQNRVELI QDFEFSEASN 60
KIKVSRDGQY CMATGTYKPQ IHVYDFANLS LKFDRHTDAE NVDFTILSDD WTKSVHLQND 120
RSIQFQNKGG LHYTTRIPKF GRSLVYNKVN CDLYVGASGN ELYRLNLEKG RFLNPFKLDT 180
EGVNHVSINE VNGLLAAGTE TNVVEFWDPR SRSRVSKLYL ENNIDNRPFQ VTTTSFRNDG 240
LTFACGTSNG YSYIYDLRTS EPSIIKDQGY GFDIKKIIWL DNVGTENKIV TCDKRIAKIW 300
DRLDGKAYAS MEPSVDINDI EHVPGTGMFF TANESIPMHT YYIPSLGPSP RWCSFLDSIT 360
EELEEKPSDT VYSNYRFITR DDVKKLNLTH LVGSRVLRAY MHGFFINTEL YDKVSLIANP 420
DAYKDERERE IRRRIEKERE SRIRSSGAVQ KPKIKVNKTL VDKLSQKRGD KVAGKVLTDD 480
RFKEMFEDEE FQVDEDDYDF KQLNPVKSIK ETEEGAAKRI RALTAAEESD EERIAMKDGR 540
GHYDYEDEES DEEESDDETN QKSNKEELSE KDLRKMEKQK ALIERRKKEK EQSERFMNEM 600
KAGTSTSTQR DESAHVTFGE QVGELLEVEN GKKSNESILR RNQRGEAELT FIPQRKSKKD 660
GNYKSRRHDN SSDEEGIDEN GNKKDNGRSK PRFENRRRAS KNAFRGM 707 
Gene Ontology
 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0042274; P:ribosomal small subunit biogenesis; IMP:SGD.
 GO:0006364; P:rRNA processing; IPI:SGD. 
Interpro
 IPR012580; NUC153.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08159; NUC153 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS