CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016691
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 59 
Protein Synonyms/Alias
 CUL4- and DDB1-associated WDR protein 12 
Gene Name
 Wdr59 
Gene Synonyms/Alias
 Cdw12; Kiaa1923 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
882TQQFDDFKKCYGEILubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 REPEAT 57 98 WD 1.
 REPEAT 103 143 WD 2.
 REPEAT 146 185 WD 3.
 REPEAT 189 229 WD 4.
 REPEAT 232 276 WD 5.
 REPEAT 278 318 WD 6.
 REPEAT 319 362 WD 7.
 DOMAIN 393 494 RWD.
 REPEAT 660 706 WD 8.
 MOD_RES 839 839 Phosphoserine.
 MOD_RES 840 840 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 992 AA 
Protein Sequence
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG HRKISRQSKW 60
DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT LQGHTRVISD LDWAVFEPDL 120
LVTSSVDTYI YIWDIKDTRK PTVALSAVAG ASQVKWNKKN ANYLATSHDG DVRIWDKRKP 180
STAVEYLAAH LSKIHGLDWH PDSEHIFATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA 240
RYTPFSNGLV TVMVPQLRRE NSLLLWNASD LNAPVHTFVG HDDVVLEFQW RRQKEGSKDY 300
QLVTWSRDQT LRMWRVDYQM QRLCANDILD GVDEFIESIS LLPEPEKTPH PQDIDHQPSL 360
SHGEEDAIKE DPPSSLLEEK RSDQLGLPQT LQQEFSLINV QIRNVNVEMD AADRSCTVSV 420
HCSNHRVKML VTFPAQYPNN AAPSFQFINP TTITSAVKAK LLKILKDTSL QKVKRNQSCL 480
EPCLRQLVSC LESFVNQEDS ASSNPFALQN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS 540
GARFCGAGYL VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY 600
SGSPTRSEKE QVSISSFYYK ERMSPRSARR RWSIQAINDF PKSRRWKSKR EGSDSGNRPI 660
KAAGKVIIQD VSCLLPVHKS LGELYILNVN DTQETCQKNA TSAMLVGRKD LVQVWSLATV 720
ATDLCLGPKS DPDLETPWAR HPFGRQLLES LLAHYCQLRD VQTLAMLCSV FEAQSRPQGL 780
PNPFGPFPNR SSNLVVSHSR YPSFTSSGSC SSMSDPGFNT GGWNIAGRET EHISSPWGES 840
SPEELRFGSL TYSDPRERER DQHDKNKRLL DPANTQQFDD FKKCYGEILY RWGLREKRAE 900
VLKFVSCPPD PHKGIEFGVY CSHCRSEVRG TQCAICKGFT FQCAICHVAV RGSSNFCLTC 960
GHGGHTSHMM EWFRTQEVCP TGCGCHCLLE STF 993 
Gene Ontology
  
Interpro
 IPR006575; RWD-domain.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00591; RWD
 SM00320; WD40 
PROSITE
 PS50908; RWD
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS