CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013566
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar MIF4G domain-containing protein 1 
Protein Synonyms/Alias
 SGD1 homolog 
Gene Name
 NOM1 
Gene Synonyms/Alias
 C7orf3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
531LITEAQTKASGAGSEubiquitination[1]
562LKNNDMRKIPGYDPEubiquitination[2]
641LVGTVSSKILELARKubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in targeting PPP1CA to the nucleolus. 
Sequence Annotation
 DOMAIN 362 559 MIF4G.
 DOMAIN 654 770 MI.
 REGION 1 269 Necessary for nucleolar localization and
 MOTIF 307 310 Required for efficient binding to PPP1CA
 MOD_RES 317 317 Phosphoserine.
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 321 321 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 860 AA 
Protein Sequence
MAASRSAGEA GPGGSQGRVV RMKRRGGRGP RRGPAGGGEK ALKRLKLAVE EFVHATSEGE 60
APGGCEGRGA PVSFRPGGRK SRKELRKEKR HLRKARRLQR TAGPEQGPGL GGRSGAEEAS 120
GHRQDTEERA RPAPSRDPSP PRKPRPSRVK AKATAATAKT RPSAAATAAA RKRALLAANE 180
EEDREIRKLE RCLGLNKRKK KDGSSSVPLS FARDGLDYIL GALESGKNSG LYDSSGEEEE 240
DAGQTLPESD LESDSQDESE EEEEGDVEKE KKAQEAEAQS EDDDEDTEEE QGEEKEKGAQ 300
EKRRGKRVRF AEDEEKSENS SEDGDITDKS LCGSGEKYIP PHVRQAEETV DFKKKEELER 360
LKKHVKGLLN RLSEPNMASI SGQLEELYMA HSRKDMNDTL TSALMGACVT ASAMPSRLMM 420
EHVLLVSILH HTVGIEVGAH FLEAVVRKFD AIYKYGSEGK ECDNLFTVIA HLYNFHVVQS 480
LLIFDILKKL IGTFTEKDIE LILLMLKNVG FSLRKDDALS LKELITEAQT KASGAGSEFQ 540
DQTRIRFMLE TMLALKNNDM RKIPGYDPEP VEKLRKLQRA LVRNAGSGSE TQLRVSWDSV 600
LSAEQTGRWW IVGSAWSGAP MIDNSHHTHL QKQLVGTVSS KILELARKQR MNTDIRRNIF 660
CTIMTSEDFL DAFEKLLKLG LKDQQEREII HVLMDCCLQE KTYNPFYAFL ASKFCEYERR 720
FQMTFQFSIW DKFRDLENLP ATNFSNLVHL VAHLLKTKSL SLSILKVVEF SELDKPRVRF 780
LRKVLSILLM ETEVEDLSLI FTRVSDNPKL GVLREGLKLF ISHFLLKNAQ AHRSADEANV 840
LREKADLATK CLQGKASLRM 860 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3. 
Pfam
 PF02847; MA3
 PF02854; MIF4G 
SMART
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI 
PRINTS