CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045207
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acyl-CoA-binding protein 
Protein Synonyms/Alias
  
Gene Name
 Dbi 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
8MSQAEFDKAAEEVKRacetylation[1, 2, 3, 4]
8MSQAEFDKAAEEVKRsuccinylation[4]
8MSQAEFDKAAEEVKRsuccinylation[4]
14DKAAEEVKRLKTQPTacetylation[1, 3]
14DKAAEEVKRLKTQPTubiquitination[5]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 77 AA 
Protein Sequence
MSQAEFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTGMPSFSSE RAKLARQPGS 60
LRTSPSDCQR QAVMTEH 77 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0001942; P:hair follicle development; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI. 
Interpro
 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 
Pfam
 PF00887; ACBP 
SMART
  
PROSITE
 PS00880; ACB_1
 PS51228; ACB_2 
PRINTS
 PR00689; ACOABINDINGP.