UniProt Accession

 XERC_SALTY; P55888 

Genbank Protein ID

 U92525; AF233324; AE006468 

Genbank Nucleotide ID

 AAC45778.1; AAF33443.1; AAL22793.1 

Protein Name

 Tyrosine recombinase XerC 

Protein Synonyms/Alias

  

Gene Name

 xerC 

Gene Synonyms/Alias

 STM3949; STMD1.41 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
160	ELVGLDIKHLDLDTG	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands (By similarity). 

Sequence Annotation

 ACT_SITE 150 150 By similarity.
 ACT_SITE 174 174 By similarity.
 ACT_SITE 242 242 By similarity.
 ACT_SITE 245 245 By similarity.
 ACT_SITE 268 268 By similarity.
 ACT_SITE 277 277 O-(3'-phospho-DNA)-tyrosine intermediate  

Keyword

 Cell cycle; Cell division; Chromosome partition; Complete proteome; Cytoplasm; DNA integration; DNA recombination; DNA-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:HAMAP.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IEA:HAMAP.
 GO:0006313; P:transposition, DNA-mediated; IEA:HAMAP. 

Interpro

 IPR011010; DNA_brk_join_enz.
 IPR013762; Integrase-like_cat-core.
 IPR002104; Integrase_catalytic.
 IPR010998; Integrase_Lambda-type_N.
 IPR023109; Integrase_recombinase_N.
 IPR004107; Integrase_SAM-like_N.
 IPR011931; Recomb_XerC.
 IPR023009; Tyrosine_recombinase_XerC/XerD. 

Pfam

 PF02899; Phage_integr_N
 PF00589; Phage_integrase 

SMART

  

PROSITE

  

PRINTS