UniProt Accession

 AQP3_HUMAN; Q92482; A8K843; B2RE16; D3DRL3; O00108; Q6FGT2; Q6FGW6 

Genbank Protein ID

 AB001325; AJ493597; CR541991; CR542025; BT007199; AK292208; AK315760; DQ083949; AL356218; CH471071; CH471071; BC013566 

Genbank Nucleotide ID

 BAA19237.1; CAD38526.1; CAG46788.1; CAG46822.1; AAP35863.1; BAF84897.1; BAG38113.1; AAY68214.1; CAI13311.1; EAW58500.1; EAW58504.1; AAH13566.1 

Protein Name

 Aquaporin-3 

Protein Synonyms/Alias

 AQP-3; Aquaglyceroporin-3 

Gene Name

 AQP3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MGRQKELVSRCG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). 

Sequence Annotation

 MOTIF 83 85 NPA 1.
 MOTIF 215 217 NPA 2.
 CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Blood group antigen; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IC:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0015254; F:glycerol channel activity; IDA:BHF-UCL.
 GO:0015250; F:water channel activity; TAS:BHF-UCL.
 GO:0007588; P:excretion; TAS:ProtInc.
 GO:0042476; P:odontogenesis; IEP:UniProtKB.
 GO:0002684; P:positive regulation of immune system process; IDA:BHF-UCL.
 GO:0045616; P:regulation of keratinocyte differentiation; TAS:BHF-UCL.
 GO:0070295; P:renal water absorption; IEA:Compara.
 GO:0051592; P:response to calcium ion; TAS:BHF-UCL.
 GO:0032526; P:response to retinoic acid; IDA:BHF-UCL.
 GO:0033280; P:response to vitamin D; TAS:BHF-UCL.
 GO:0015840; P:urea transport; IEA:Compara. 

Interpro

 IPR023271; Aquaporin-like.
 IPR023275; Aquaporin_3.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR02015; AQUAPORIN3.
 PR00783; MINTRINSICP.