UniProt Accession

 RHO4_YEAST; Q00246; D6VXB6; P30618 

Genbank Protein ID

 Z25734; D10007; Z14126; Z28280; AY557909; BK006944 

Genbank Nucleotide ID

 CAA81020.1; BAA00898.1; CAA78500.1; CAA82133.1; AAS56235.1; DAA09206.1 

Protein Name

 GTP-binding protein RHO4 

Protein Synonyms/Alias

  

Gene Name

 RHO4 

Gene Synonyms/Alias

 YKR055W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
40	SPGTLDEKNLPRLPT	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways. 

Sequence Annotation

 NP_BIND 79 86 GTP (By similarity).
 NP_BIND 127 131 GTP (By similarity).
 NP_BIND 185 188 GTP (By similarity).
 MOTIF 101 109 Effector region (By similarity).
 MOD_RES 264 264 Phosphoserine.
 MOD_RES 268 268 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 288 288 Cysteine methyl ester (By similarity).
 LIPID 288 288 S-farnesyl cysteine (By similarity).  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 291 AA 

Protein Sequence

Gene Ontology

 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0030011; P:maintenance of cell polarity; IGI:SGD.
 GO:0090338; P:positive regulation of formin-nucleated actin cable assembly; IGI:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.