CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004665
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor AP-1 
Protein Synonyms/Alias
 Jun-related antigen; dJRA; dJun 
Gene Name
 Jra 
Gene Synonyms/Alias
 jun; CG2275 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
112MQTPQPGKVFPTKAGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. 
Sequence Annotation
 DOMAIN 212 275 bZIP.
 REGION 212 239 Basic motif (By similarity).
 REGION 240 268 Leucine-zipper (By similarity).
 MOD_RES 82 82 Phosphoserine.  
Keyword
 Activator; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 289 AA 
Protein Sequence
MKTPVSAAAN LSIQNAGSSG ATAIQIIPKT EPVGEEGPMS LDFQSPNLNT STPNPNKRPG 60
SLDLNSKSAK NKRIFAPLVI NSPDLSSKTV NTPDLEKILL SNNLMQTPQP GKVFPTKAGP 120
VTVEQLDFGR GFEEALHNLH TNSQAFPSAN SAANSAANNT TAAAMTAVNN GISGGTFTYT 180
NMTEGFSVIK DEPVNQASSP TVNPIDMEAQ EKIKLERKRQ RNRVAASKCR KRKLERISKL 240
EDRVKVLKGE NVDLASIVKN LKDHVAQLKQ QVMEHIAAGC TVPPNSTDQ 289 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005667; C:transcription factor complex; IPI:FlyBase.
 GO:0046982; F:protein heterodimerization activity; ISS:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:FlyBase.
 GO:0008134; F:transcription factor binding; TAS:FlyBase.
 GO:0046843; P:dorsal appendage formation; IMP:FlyBase.
 GO:0007391; P:dorsal closure; NAS:FlyBase.
 GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.
 GO:0007254; P:JNK cascade; IMP:FlyBase.
 GO:0046844; P:micropyle formation; IMP:FlyBase.
 GO:0008348; P:negative regulation of antimicrobial humoral response; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
 GO:0007464; P:R3/R4 cell fate commitment; TAS:FlyBase.
 GO:0007465; P:R7 cell fate commitment; TAS:FlyBase.
 GO:0051124; P:synaptic growth at neuromuscular junction; IGI:FlyBase.
 GO:0042060; P:wound healing; IMP:FlyBase. 
Interpro
 IPR004827; bZIP.
 IPR008917; Euk_TF_DNA-bd.
 IPR005643; JNK.
 IPR002112; Leuzip_Jun. 
Pfam
 PF00170; bZIP_1
 PF03957; Jun 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS
 PR00043; LEUZIPPRJUN.