UniProt Accession

 DHE3_BOVIN; P00366; Q3SYY0; Q7YS29; Q8HZ49 

Genbank Protein ID

 AY138843; AY256856; BC103336 

Genbank Nucleotide ID

 AAN15276.1; AAP55683.1; AAI03337.1 

Protein Name

 Glutamate dehydrogenase 1, mitochondrial 

Protein Synonyms/Alias

 GDH 1 

Gene Name

 GLUD1 

Gene Synonyms/Alias

 GLUD 

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
84	GASIVEDKLVEDLKT	succinylation	[1]
110	RSILRIIKPCNHVLS	succinylation	[1]
162	DVSVDEVKALASLMT	succinylation	[1]
363	GTILGFPKAKIYEGS	succinylation	[1]
415	PTTPEADKIFLERNI	succinylation	[1]
457	SYGRLTFKYERDSNY	malonylation	[1]
457	SYGRLTFKYERDSNY	succinylation	[1]
503	RISGASEKDIVHSGL	malonylation	[1]
503	RISGASEKDIVHSGL	succinylation	[1]
527	QIMRTAMKYNLGLDL	malonylation	[1]
527	QIMRTAMKYNLGLDL	succinylation	[1]
545	AYVNAIEKVFRVYNE	succinylation	[1]

Reference

 [1] Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
 Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H.
 Science. 2011 Nov 11;334(6057):806-9. [PMID: 22076378] 

Functional Description

 May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). 

Sequence Annotation

 NP_BIND 141 143 NAD.
 ACT_SITE 183 183
 BINDING 147 147 Substrate.
 BINDING 171 171 Substrate.
 BINDING 176 176 NAD.
 BINDING 252 252 NAD.
 BINDING 266 266 GTP.
 BINDING 270 270 GTP.
 BINDING 319 319 GTP.
 BINDING 322 322 GTP.
 BINDING 438 438 Substrate.
 BINDING 444 444 NAD.
 BINDING 450 450 ADP.
 BINDING 516 516 ADP.
 MOD_RES 84 84 N6-acetyllysine; alternate.
 MOD_RES 84 84 N6-succinyllysine; alternate.
 MOD_RES 90 90 N6-acetyllysine.
 MOD_RES 110 110 N6-acetyllysine; alternate.
 MOD_RES 110 110 N6-succinyllysine; alternate.
 MOD_RES 135 135 Phosphotyrosine (By similarity).
 MOD_RES 162 162 N6-acetyllysine; alternate.
 MOD_RES 162 162 N6-succinyllysine; alternate.
 MOD_RES 172 172 ADP-ribosylcysteine (By similarity).
 MOD_RES 183 183 N6-acetyllysine.
 MOD_RES 191 191 N6-acetyllysine.
 MOD_RES 227 227 Phosphoserine (By similarity).
 MOD_RES 363 363 N6-acetyllysine; alternate.
 MOD_RES 363 363 N6-succinyllysine; alternate.
 MOD_RES 365 365 N6-acetyllysine.
 MOD_RES 386 386 N6-acetyllysine.
 MOD_RES 399 399 N6-acetyllysine.
 MOD_RES 415 415 N6-acetyllysine; alternate.
 MOD_RES 415 415 N6-succinyllysine; alternate.
 MOD_RES 450 450 Phosphoserine (By similarity).
 MOD_RES 457 457 N6-acetyllysine; alternate.
 MOD_RES 457 457 N6-malonyllysine; alternate.
 MOD_RES 457 457 N6-succinyllysine; alternate.
 MOD_RES 480 480 N6-acetyllysine.
 MOD_RES 503 503 N6-acetyllysine; alternate.
 MOD_RES 503 503 N6-malonyllysine; alternate.
 MOD_RES 503 503 N6-succinyllysine; alternate.
 MOD_RES 512 512 Phosphotyrosine (By similarity).
 MOD_RES 527 527 N6-acetyllysine; alternate.
 MOD_RES 527 527 N6-malonyllysine; alternate.
 MOD_RES 527 527 N6-succinyllysine; alternate.
 MOD_RES 545 545 N6-acetyllysine; alternate.
 MOD_RES 545 545 N6-succinyllysine; alternate.  

Keyword

 3D-structure; Acetylation; ADP-ribosylation; ATP-binding; Complete proteome; Direct protein sequencing; GTP-binding; Mitochondrion; NADP; Nucleotide-binding; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; ISS:AgBase.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004352; F:glutamate dehydrogenase (NAD+) activity; ISS:AgBase.
 GO:0004353; F:glutamate dehydrogenase [NAD(P)+] activity; ISS:AgBase.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006538; P:glutamate catabolic process; ISS:AgBase.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara. 

Interpro

 IPR006095; Glu/Leu/Phe/Val_DH.
 IPR006096; Glu/Leu/Phe/Val_DH_C.
 IPR006097; Glu/Leu/Phe/Val_DH_dimer_dom.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00208; ELFV_dehydrog
 PF02812; ELFV_dehydrog_N 

SMART

 SM00839; ELFV_dehydrog 

PROSITE

 PS00074; GLFV_DEHYDROGENASE 

PRINTS

 PR00082; GLFDHDRGNASE.