| Tag | Content |
|---|
| CPLM ID | CPLM-008920 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Delta-1-pyrroline-5-carboxylate synthase |
Protein Synonyms/Alias | P5CS; Aldehyde dehydrogenase family 18 member A1; Glutamate 5-kinase; GK; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase |
Gene Name | ALDH18A1 |
Gene Synonyms/Alias | GSAS; P5CS; PYCS |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 149 | HSGQNQLKEMAIPVL | ubiquitination | [1] | | 298 | QSVTFGTKSRVGMGG | ubiquitination | [1] | | 309 | GMGGMEAKVKAALWA | ubiquitination | [1] | | 345 | ITDIVEGKKVGTFFS | ubiquitination | [1] | | 346 | TDIVEGKKVGTFFSE | ubiquitination | [1] | | 355 | GTFFSEVKPAGPTVE | ubiquitination | [1] | | 406 | DEILLANKKDLEEAE | ubiquitination | [1] | | 660 | TFSPSEVKSLRTEYG | ubiquitination | [1] | | 765 | TKWLLRGKDHVVSDF | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. |
Sequence Annotation | NP_BIND 266 267 ATP (By similarity).
NP_BIND 305 311 ATP (By similarity).
REGION 1 361 Glutamate 5-kinase.
REGION 362 795 Gamma-glutamyl phosphate reductase.
BINDING 117 117 Substrate (By similarity).
BINDING 223 223 Substrate (By similarity).
BINDING 246 246 Substrate; via amide nitrogen (By |
Keyword | 3D-structure; Alternative splicing; Amino-acid biosynthesis; ATP-binding; Complete proteome; Disease mutation; Kinase; Membrane; Mental retardation; Mitochondrion; Mitochondrion inner membrane; Multifunctional enzyme; NADP; Nucleotide-binding; Oxidoreductase; Polymorphism; Proline biosynthesis; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 795 AA |
Protein Sequence | MLSQVYRCGF QPFNQHLLPW VKCTTVFRSH CIQPSVIRHV RSWSNIPFIT VPLSRTHGKS 60
FAHRSELKHA KRIVVKLGSA VVTRGDECGL ALGRLASIVE QVSVLQNQGR EMMLVTSGAV 120
AFGKQRLRHE ILLSQSVRQA LHSGQNQLKE MAIPVLEARA CAAAGQSGLM ALYEAMFTQY 180
SICAAQILVT NLDFHDEQKR RNLNGTLHEL LRMNIVPIVN TNDAVVPPAE PNSDLQGVIS 240
VKDNDSLAAR LAVEMKTDLL IVLSDVEGLF DSPPGSDDAK LIDIFYPGDQ QSVTFGTKSR 300
VGMGGMEAKV KAALWALQGG TSVVIANGTH PKVSGHVITD IVEGKKVGTF FSEVKPAGPT 360
VEQQGEMARS GGRMLATLEP EQRAEIIHHL ADLLTDQRDE ILLANKKDLE EAEGRLAAPL 420
LKRLSLSTSK LNSLAIGLRQ IAASSQDSVG RVLRRTRIAK NLELEQVTVP IGVLLVIFES 480
RPDCLPQVAA LAIASGNGLL LKGGKEAAHS NRILHLLTQE ALSIHGVKEA VQLVNTREEV 540
EDLCRLDKMI DLIIPRGSSQ LVRDIQKAAK GIPVMGHSEG ICHMYVDSEA SVDKVTRLVR 600
DSKCEYPAAC NALETLLIHR DLLRTPLFDQ IIDMLRVEQV KIHAGPKFAS YLTFSPSEVK 660
SLRTEYGDLE LCIEVVDNVQ DAIDHIHKYG SSHTDVIVTE DENTAEFFLQ HVDSACVFWN 720
ASTRFSDGYR FGLGAEVGIS TSRIHARGPV GLEGLLTTKW LLRGKDHVVS DFSEHGSLKY 780
LHENLPIPQR NTN 793 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004349; F:glutamate 5-kinase activity; IDA:UniProtKB. GO:0004350; F:glutamate-5-semialdehyde dehydrogenase activity; IDA:UniProtKB. GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome. GO:0019240; P:citrulline biosynthetic process; IMP:UniProtKB. GO:0006536; P:glutamate metabolic process; IMP:UniProtKB. GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006592; P:ornithine biosynthetic process; IMP:UniProtKB. GO:0006561; P:proline biosynthetic process; IMP:UniProtKB. |
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Pfam | |
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PROSITE | |
PRINTS | |