CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S protease regulatory subunit 6B 
Protein Synonyms/Alias
 26S proteasome AAA-ATPase subunit RPT3; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; Tat-binding protein 7; TBP-7 
Gene Name
 PSMC4 
Gene Synonyms/Alias
 MIP224; TBP7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94TIDRELLKPNASVALubiquitination[1]
161LTHFELYKQIGIDPPubiquitination[1]
186CGKTMLAKAVAHHTTubiquitination[1]
207VGSEFVQKYLGEGPRubiquitination[1]
224RDVFRLAKENAPAIIubiquitination[1]
242EIDAIATKRFDAQTGubiquitination[1]
366NRYIVLAKDFEKAYKubiquitination[1]
378AYKTVIKKDEQEHEFubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 
Sequence Annotation
 NP_BIND 206 213 ATP (Potential).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 397 397 N6-acetyllysine.
 MOD_RES 401 401 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKEEVKR IQSIPLVIGQ 60
FLEAVDQNTA IVGSTTGSNY YVRILSTIDR ELLKPNASVA LHKHSNALVD VLPPEADSSI 120
MMLTSDQKPD VMYADIGGMD IQKQEVREAV ELPLTHFELY KQIGIDPPRG VLMYGPPGCG 180
KTMLAKAVAH HTTAAFIRVV GSEFVQKYLG EGPRMVRDVF RLAKENAPAI IFIDEIDAIA 240
TKRFDAQTGA DREVQRILLE LLNQMDGFDQ NVNVKVIMAT NRADTLDPAL LRPGRLDRKI 300
EFPLPDRRQK RLIFSTITSK MNLSEEVDLE DYVARPDKIS GADINSICQE SGMLAVRENR 360
YIVLAKDFEK AYKTVIKKDE QEHEFYK 387 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; TAS:ProtInc.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0006915; P:apoptotic process; TAS:Reactome.
 GO:0001824; P:blastocyst development; IEA:Compara.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0016071; P:mRNA metabolic process; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0000209; P:protein polyubiquitination; TAS:Reactome.
 GO:0042981; P:regulation of apoptotic process; TAS:Reactome.
 GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome. 
Interpro
 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS