CPLM-000974

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-000974

UniProt Accession

PLIN3_HUMAN; O60664; A8K4Y9; K7EQF4; Q53G77; Q9BS03; Q9UBD7; Q9UP92

Genbank Protein ID

AF057140; AF055574; AF051314; AF051315; BT007235; AK291104; AK223054; AK225045; AC027319; BC001590; BC005818; BC007566; BC019278

Genbank Nucleotide ID

AAC39751.1; AAD11622.1; AAD11619.1; AAD11620.1; AAP35899.1; BAF83793.1; BAD96774.1; AAH01590.1; AAH05818.1; AAH07566.1; AAH19278.1

Protein Name

Perilipin-3

Protein Synonyms/Alias

47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; Placental protein 17; PP17

Gene Name

PLIN3

Gene Synonyms/Alias

M6PRBP1; TIP47

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
84	GAQPILSKLEPQIAS	ubiquitination	[1]
122	EKVLADTKELVSSKV	ubiquitination	[1]
128	TKELVSSKVSGAQEM	ubiquitination	[1]
195	GVDTVLGKSEEWADN	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.

Sequence Annotation

MOD_RES 2 2 N-acetylserine.
MOD_RES 65 65 N6-acetyllysine.
MOD_RES 130 130 Phosphoserine.
MOD_RES 170 170 Phosphothreonine.
MOD_RES 175 175 Phosphoserine.
MOD_RES 179 179 Phosphoserine.

Keyword

Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endosome; Lipid droplet; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

434 AA

Protein Sequence

MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC 60
DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD 120
TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR 180
LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG 240
SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM 300
WLSWNQKQLQ GPEKEPPKPE VESRALTMFR DIAQQLQATC TSLGSSIQGL PTNVKDQVQQ 360
ARRQVEDLQA TFSSIHSFQD LSSSILAQSR ERVASAREAL DHMVEYVAQN TPVTWLVGPF 420
APGITEKAPE EKK 433

Gene Ontology

GO:0005768; C:endosome; TAS:ProtInc.
GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; TAS:ProtInc.
GO:0005811; C:lipid particle; IDA:UniProtKB.
GO:0016192; P:vesicle-mediated transport; TAS:ProtInc.

Interpro

IPR004279; Perilipin.

Pfam

PF03036; Perilipin

SMART

PROSITE

PRINTS