UniProt Accession

 FHL3_MOUSE; Q9R059; A6H6N4; Q9JLP5; Q9WUH3 

Genbank Protein ID

 AF134772; AF114382; AL606907; BC144903; BC145939; AF149826 

Genbank Nucleotide ID

 AAD32623.1; AAD53231.1; AAI44904.1; AAI45940.1; AAF73159.1 

Protein Name

 Four and a half LIM domains protein 3 

Protein Synonyms/Alias

 FHL-3; Skeletal muscle LIM-protein 2; SLIM-2 

Gene Name

 Fhl3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
167	PRCARCSKTLTQGGV	ubiquitination	[1]
192	CLVCTGCKTPLAGQQ	ubiquitination	[1]
244	GAGLGGGKYVSFEDR	acetylation	[2, 3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

 DOMAIN 40 92 LIM zinc-binding 1.
 DOMAIN 101 153 LIM zinc-binding 2.
 DOMAIN 162 212 LIM zinc-binding 3.
 DOMAIN 221 275 LIM zinc-binding 4.
 ZN_FING 7 31 C4-type (Potential).  

Keyword

 Complete proteome; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IDA:MGI. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS