CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030009
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alcohol dehydrogenase [NADP(+)] 
Protein Synonyms/Alias
  
Gene Name
 Akr1a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
13VLLHTGQKMPLIGLGubiquitination[1]
23LIGLGTWKSEPGQVKacetylation[2, 3, 4]
23LIGLGTWKSEPGQVKsuccinylation[4]
23LIGLGTWKSEPGQVKubiquitination[1]
30KSEPGQVKAAIKHALubiquitination[1]
34GQVKAAIKHALSAGYacetylation[3]
34GQVKAAIKHALSAGYubiquitination[1]
68KESVGSGKAVPREELacetylation[4]
68KESVGSGKAVPREELsuccinylation[4]
68KESVGSGKAVPREELubiquitination[1]
85TSKLWNTKHHPEDVEacetylation[3]
85TSKLWNTKHHPEDVEubiquitination[1]
127RGDNPFPKNADGTVRacetylation[2, 3, 4, 5, 6, 7, 8]
127RGDNPFPKNADGTVRsuccinylation[4]
127RGDNPFPKNADGTVRubiquitination[1]
141RYDSTHYKETWKALEacetylation[2, 3]
141RYDSTHYKETWKALEubiquitination[1]
145THYKETWKALEVLVAacetylation[4]
145THYKETWKALEVLVAsuccinylation[4]
145THYKETWKALEVLVAubiquitination[1]
153ALEVLVAKGLVKALGacetylation[3]
153ALEVLVAKGLVKALGubiquitination[1]
157LVAKGLVKALGLSNFacetylation[3]
157LVAKGLVKALGLSNFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [8] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 204 AA 
Protein Sequence
MTASSVLLHT GQKMPLIGLG TWKSEPGQVK AAIKHALSAG YRHIDCASVY GNETEIGEAL 60
KESVGSGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 120
GDNPFPKNAD GTVRYDSTHY KETWKALEVL VAKGLVKALG LSNFNSRQID DVLSVASVRP 180
AVLQVECHPY LAQNELIAHC HARG 204 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:MGI.
 GO:0047939; F:L-glucuronate reductase activity; IDA:MGI.
 GO:0046185; P:aldehyde catabolic process; IDA:MGI.
 GO:0042840; P:D-glucuronate catabolic process; IDA:MGI.
 GO:0019853; P:L-ascorbic acid biosynthetic process; IDA:MGI. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2 
PRINTS
 PR00069; ALDKETRDTASE.