CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Fascin 
Protein Synonyms/Alias
  
Gene Name
 Fscn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
212DYNKVALKVGGRYLKacetylation[1]
219KVGGRYLKGDHAGVLacetylation[1, 2, 3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 241 AA 
Protein Sequence
XSVHIAMHPQ VVLQAANERN VSTRQGMDLS ANQDEETDQE TFQLEIDRDT RKCAFRTHTG 60
KYWTLTATGG VQSTASTKNA SCYFDIEWCD RRITLRASNG KFVTAKKNGQ LAASVETAGD 120
SELFLMKLIN RPIIVFRGEH GFIGCRKVTG TLDANRSSYD VFQLEFNDGA YNIKDSTGKY 180
WTVGSDSSVT SSSDTPVDFF LEFCDYNKVA LKVGGRYLKG DHAGVLKACA ETIDPASLWE 240
Y 241 
Gene Ontology
 GO:0030175; C:filopodium; IDA:MGI.
 GO:0051015; F:actin filament binding; IMP:MGI.
 GO:0051017; P:actin filament bundle assembly; IDA:MGI. 
Interpro
 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain. 
Pfam
 PF06268; Fascin 
SMART
  
PROSITE
  
PRINTS