UniProt Accession

 RUNX3_HUMAN; Q13761; B1AJV5; Q12969; Q13760 

Genbank Protein ID

 Z35278; X79550; AL023096; AL445471; AL023096; AL023096; AL445471; CH471134; BC013362; U14520 

Genbank Nucleotide ID

 CAA84541.1; CAA56093.2; CAA18856.1; CAC42093.2; CAC42093.2; CAI20422.1; CAI20422.1; EAW95148.1; AAH13362.1; AAA86465.1 

Protein Name

 Runt-related transcription factor 3 

Protein Synonyms/Alias

 Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit 

Gene Name

 RUNX3 

Gene Synonyms/Alias

 AML2; CBFA3; PEBP2A3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	RNASAVMKNQVARFN	ubiquitination	[1]
148	VGRSGRGKSFTLTIT	acetylation	[2]
186	EPRRHRQKLEDQTKP	acetylation	[2]
192	QKLEDQTKPFPDRFG	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.
 Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC.
 J Biol Chem. 2004 Jul 9;279(28):29409-17. [PMID: 15138260] 

Functional Description

 CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. 

Sequence Annotation

 DOMAIN 54 182 Runt.
 MOD_RES 243 243 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0000790; C:nuclear chromatin; ISS:BHF-UCL.
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:BHF-UCL.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; ISS:BHF-UCL.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0031069; P:hair follicle morphogenesis; IEA:Compara.
 GO:0006917; P:induction of apoptosis; ISS:UniProtKB.
 GO:0032609; P:interferon-gamma production; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
 GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0048935; P:peripheral nervous system neuron development; TAS:BHF-UCL.
 GO:0006468; P:protein phosphorylation; IDA:UniProtKB. 

Interpro

 IPR000040; AML1_Runt.
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR013524; Runt_dom.
 IPR027384; Runx_central_dom.
 IPR013711; RunxI_C_dom.
 IPR016554; TF_Runt-rel_RUNX. 

Pfam

 PF00853; Runt
 PF08504; RunxI 

SMART

  

PROSITE

 PS51062; RUNT 

PRINTS

 PR00967; ONCOGENEAML1.