CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020608
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable cation-transporting ATPase 13A2 
Protein Synonyms/Alias
  
Gene Name
 Atp13a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
208LQDQATRKTIYGPNVubiquitination[1]
501LRINLGGKLRLVCFDubiquitination[1]
686RVVALAGKPLPIAPSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in regulating intracellular cation homeostasis and neuronal integrity (By similarity). 
Sequence Annotation
 ACT_SITE 508 508 4-aspartylphosphate intermediate (By
 METAL 867 867 Magnesium (By similarity).
 METAL 871 871 Magnesium (By similarity).  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Lysosome; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1169 AA 
Protein Sequence
MSADSSLLMG STPPSYGTLT TGTSIDPLSS SASSVRLSGY CGSPWRAIGY HAAVWMLAGI 60
PWLLFRWKPL WGVRLRLKPC SLAHAETLVI EIKDKEGSSR QLFTVQVQTE AVVQGSLELP 120
PQAQAEDGRS QAAVGVTPEG TWQDTSELHR QEEAKQVLRY YVLQGQRYVW METQQAFCQV 180
SLLDHGRTCD DVHCSSSGLS LQDQATRKTI YGPNVISIPV KSYLQLLADE ALNPYYGFQA 240
FSIALWLADH YYWYALCIFL ISAISICLAL YKTRKQSLTL RDMVKLSVRV QVCRPGGEEE 300
WVDSSELVPG DCLVLPQEGG VMPCDAALVA GECVVNESSL TGESTPVLKT ALPEGPKPYC 360
PETHRRHTLF CGTLILQARA YVGPRVLAVV TRTGFCTAKG GLVSSILHPR PISFKFYKHS 420
MKFVAALSVL ALLGTVYSII ILYRNRVPVR EIVIRALDLV TVVVPPALPA AMTVCTLYAQ 480
SRLRTQGIFC IHPLRINLGG KLRLVCFDKT GTLTEDGLDV MGVVPLKGQV LLPLVPEPCH 540
LPLGPLLRAL ATCHALSQLH DTPVGDPMDL KMVESTGWVL EEGPAAGSAP GSQVLVVMRP 600
PPGGPRQQEE PPVPVSVLCR FPFSSALQRM DVVVTWPGAT QPEAYVKGSP ELVASLCSPE 660
TVPSDFSQVL QSYTAAGYRV VALAGKPLPI APSLAAAQQL TRDTVERELS LLGLLVMRNL 720
LKPQTAPVIQ TLRKTGIRTV MVTGDNLQTA VTVARACGMV GAQEHLAVIH ATHPEQGQPA 780
ALEFLPTESS AVMNGAKATG YPTVPEPQSC HLALSGSTFA VLRKHFPKLL PKVLVQATVF 840
ARMAPEQKTE LVCELQRLQY CVGMCGDGAN DCGALKAADV GISLSQAEAS VVSPFTSSMA 900
SIECVPTVIR EGRCSLDTSF SVFKYMALYS LTQFISVLIL YTINTNLGDL QFLAIDLVIT 960
TTVAVLMSRT GPALTLVRAR PPGALLSVPV LGSLLLQVAL VAGIQLGGYF LVIAQPWFVP 1020
LNRTVPAPDN LPNYENTVVF SLSGFQYLIL AAAVSKGAPF RQPLYTNVPF LVALALLGSV 1080
LVGLILVPGL LQGPLGLRNI VDSSFKLLLL GLVAFNFVGA FMLESVLDQC LPACLRWLRP 1140
KRASKKQFKR LQQELAEHPW PTLPVGSVR 1169 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR006544; ATPase_P-typ_Cation_typ_V.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00122; E1-E2_ATPase
 PF12409; P5-ATPase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.
 PR00120; HATPASE.