| Tag | Content |
|---|
| CPLM ID | CPLM-007254 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Golgi to ER traffic protein 2 |
Protein Synonyms/Alias | Guided entry of tail-anchored proteins 2; Hydroxyurea resistance protein 2; Required for meiotic nuclear division protein 7 |
Gene Name | GET2 |
Gene Synonyms/Alias | HUR2; RMD7; YER083C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 226 | VEHKSKIKNLQDTNK | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function. |
Sequence Annotation | MOD_RES 45 45 Phosphoserine.
CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
CARBOHYD 196 196 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 285 AA |
Protein Sequence | MSELTEAEKR RLLRERRQKK FSNGGASSRL NKITGQASSH LNAESPLDAP SAAKTTPPAS 60
VHSATPDIKE DSNVAPQLDL LKQLAAMQGQ GTGKSTPQDS STPDLLSLLS SMNTGMPSAE 120
GTPSFGQAAP AAPINQAALD YHDYLLNRLK AWTILVKWVF FLLPYLYLIT RPNSSVWPAY 180
AFTQSAWFAP LRNPSNFTRI FATFEFLSIS IYYQLLKNVE HKSKIKNLQD TNKLVKLVSL 240
VPEGVIPVAN LKGKLITLLQ YWDLLSMLIT DISFVLIVLG LLTYL 285 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0043529; C:GET complex; IGI:SGD. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; ISM:SGD. GO:0043495; F:protein anchor; IGI:SGD. GO:0045048; P:protein insertion into ER membrane; IGI:SGD. GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IDA:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |