CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022984
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Importin-11 
Protein Synonyms/Alias
 Imp11; Ran-binding protein 11; RanBP11 
Gene Name
 IPO11 
Gene Synonyms/Alias
 RANBP11 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256ERTLLSLKVLRKLTVubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). 
Sequence Annotation
 DOMAIN 28 100 Importin N-terminal.
 REPEAT 123 160 HEAT 1.
 REPEAT 209 248 HEAT 2.
 REPEAT 318 356 HEAT 3.
 REPEAT 422 459 HEAT 4.
 REPEAT 473 509 HEAT 5.
 REPEAT 511 548 HEAT 6.
 REPEAT 555 593 HEAT 7.
 REPEAT 600 636 HEAT 8.
 REPEAT 640 677 HEAT 9.
 REPEAT 683 720 HEAT 10.
 REPEAT 743 764 HEAT 11.
 REPEAT 765 804 HEAT 12.
 REPEAT 819 849 HEAT 13.
 REPEAT 850 887 HEAT 14.
 REPEAT 957 974 HEAT 15.
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Protein transport; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 975 AA 
Protein Sequence
MVQPIIHLGY VVYSLLYLGY KPVQHVTALN TVSSCHKMVS MDLNSASTVV LQVLTQATSQ 60
DTAVLKPAEE QLKQWETQPG FYSVLLNIFT NHTLDINVRW LAVLYFKHGI DRYWRRVAPH 120
ALSEEEKTTL RAGLITNFNE PINQIATQIA VLIAKVARLD CPRQWPELIP TLIESVKVQD 180
DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYNF ACSLWNHHTD TFLQEVSSGN 240
EAAILSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH GIFERLKQFL ECSRSIGTDN 300
VCRDRLEKTI ILFTKVLLDF LDQHPFSFTP LIQRSLEFSV SYVFTEVGEG VTFERFIVQC 360
MNLIKMIVKN YAYKPSKNFE DSSPETLEAH KIKMAFFTYP TLTEICRRLV SHYFLLTEEE 420
LTMWEEDPEG FTVEETGGDS WKYSLRPCTE VLFIDIFHEY NQTLTPVLLE MMQTLQGPTN 480
VEDMNALLIK DAVYNAVGLA AYELFDSVDF DQWFKNQLLP ELQVIHNRYK PLRRRVIWLI 540
GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK LTVDDFEFRT DQFLPYLETM 600
FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNMQIRPYVG CLVQYLPLLW KQSEEHNMLR 660
CAILTTLIHL VQGLGADSKN LYPFLLPVIQ LSTDVSQPPH VYLLEDGLEL WLVTLENSPC 720
ITPELLRIFQ NMSPLLELSS ENLRTCFKII NGYIFLSSTE FLQTYAVGLC QSFCELLKEI 780
TTEGQVQVLK VVENALKVNP ILGPQMFQPI LPYVFKGIIE GERYPVVMST YLGVMGRVLL 840
QNTSFFSSLL NEMAHKFNQE MDQLLGNMIE MWVDRMDNIT QPERRKLSAL ALLSLLPSDN 900
SVIQDKFCGI INISVEGLHD VMTEDPETGT YKDCMLMSHL EEPKVTEDEE PPTEQDKRKK 960
MLALKDPVHT VSLQQFIYEK LKAQQEMLGE QGFQSLMETV DTEIVTQLQE FLQGF 1015 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:Compara.
 GO:0006610; P:ribosomal protein import into nucleus; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001494; Importin-beta_N. 
Pfam
 PF03810; IBN_N 
SMART
 SM00913; IBN_N 
PROSITE
 PS50077; HEAT_REPEAT
 PS50166; IMPORTIN_B_NT 
PRINTS