CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018482
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cold shock domain-containing protein E1 
Protein Synonyms/Alias
  
Gene Name
 Csde1 
Gene Synonyms/Alias
 D3Jfr1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
91AIKLVKIKPEIHPEEubiquitination[1]
166NFVIDNNKHTGAVSAubiquitination[1]
239TIKDRNGKEVATDVRubiquitination[1]
277VIPKVPSKNQNDPLPubiquitination[1]
288DPLPGRIKVDFVIPKubiquitination[1]
452SPNKGKDKEAEDGIIacetylation[2]
488TSPQIGDKVEFSISDubiquitination[1]
682RATVECVKDQFGFINacetylation[2]
682RATVECVKDQFGFINubiquitination[1]
758DRLVNRLKNITLDDAacetylation[2]
758DRLVNRLKNITLDDAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). 
Sequence Annotation
 DOMAIN 26 87 CSD 1.
 DOMAIN 136 179 CSD 2; truncated.
 DOMAIN 186 245 CSD 3.
 DOMAIN 297 337 CSD 4; truncated.
 DOMAIN 349 410 CSD 5.
 DOMAIN 447 507 CSD 6.
 DOMAIN 519 579 CSD 7.
 DOMAIN 610 670 CSD 8.
 DOMAIN 674 735 CSD 9.
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 123 123 Phosphoserine (By similarity).
 MOD_RES 514 514 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 798 AA 
Protein Sequence
MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF FHCSQYNGNL 60
QDLKVGDDVE FEVSSDRRTG KPIAIKLVKI KPEIHPEERM NGQVVCAVPH NLESKSPAAP 120
GQSPTGSVCY ERNGEVFYLT YTSEDVEGNV QLETGDKINF VIDNNKHTGA VSARNIMLLK 180
KKQARCQGVV CAMKEAFGFI ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE 240
VATDVRLLPQ GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG 300
DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM GVIAAMRDGF 360
GFIKCVDRDA RMFFHFSEIL DGNQLHIADE VEFTVVPDML SAQRNHAIRI KKLPKGTVSF 420
HSHSDHRFLG TVEKEATFSN PKTTSPNKGK DKEAEDGIIA YDDCGVKLTI AFQAKDVEGS 480
TSPQIGDKVE FSISDKQRPG QQIATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK 540
EIFFHYSEFS GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KAHSVNGITE EANPTIYSGK 600
VIRPLRGVDP TQIEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE SVKFQLCVLG 660
QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF HVKEVQDGVE LQAGDEVEFS 720
VILNQRTGKC SACNVWRVCE GPKAVAAPRP DRLVNRLKNI TLDDASAPRL MVLRQPRGPD 780
NSMGFGAERK IRQAGVID 798 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR019844; Cold-shock_CS.
 IPR011129; Cold_shock_prot.
 IPR002059; CSP_DNA-bd.
 IPR012340; NA-bd_OB-fold.
 IPR024642; SUZ-C. 
Pfam
 PF00313; CSD
 PF12901; SUZ-C 
SMART
 SM00357; CSP 
PROSITE
 PS00352; COLD_SHOCK 
PRINTS