UniProt Accession

 PGPI_MOUSE; Q9ESW8 

Genbank Protein ID

 AJ278829; AK003373; AK012658; AK047835; AK049632; BC051938 

Genbank Nucleotide ID

 CAC03615.1; BAB22746.1; BAB28388.1; BAC33170.1; BAC33848.1; AAH51938.1 

Protein Name

 Pyroglutamyl-peptidase 1 

Protein Synonyms/Alias

 5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase 

Gene Name

 Pgpep1 

Gene Synonyms/Alias

 Pgpi 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
94	CGHNKGYKGLDNCRF	ubiquitination	[1]
174	VHVPPLGKPYNADQL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity). 

Sequence Annotation

 ACT_SITE 85 85 By similarity.
 ACT_SITE 149 149 By similarity.
 ACT_SITE 168 168 By similarity.  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome; Thiol protease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0008233; F:peptidase activity; ISA:MGI.
 GO:0006508; P:proteolysis; ISA:MGI. 

Interpro

 IPR000816; Peptidase_C15.
 IPR016125; Peptidase_C15-like. 

Pfam

 PF01470; Peptidase_C15 

SMART

  

PROSITE

 PS01334; PYRASE_CYS
 PS01333; PYRASE_GLU 

PRINTS

 PR00706; PYROGLUPTASE.