UniProt Accession

 NDUV2_RAT; P19234; Q6PDU9 

Genbank Protein ID

 BC058495; M22756 

Genbank Nucleotide ID

 AAH58495.1; AAA41669.1 

Protein Name

 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 

Protein Synonyms/Alias

 NADH-ubiquinone oxidoreductase 24 kDa subunit 

Gene Name

 Ndufv2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
158	LQRKLGIKVGETTPD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 METAL 134 134 Iron-sulfur (2Fe-2S) (Potential).
 METAL 139 139 Iron-sulfur (2Fe-2S) (Potential).
 METAL 175 175 Iron-sulfur (2Fe-2S) (Potential).
 METAL 179 179 Iron-sulfur (2Fe-2S) (Potential).
 MOD_RES 192 192 Phosphotyrosine; by SRC (By similarity).  

Keyword

 2Fe-2S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IBA:RefGenome.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:RefGenome.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:RefGenome.
 GO:0007399; P:nervous system development; IEA:Compara. 

Interpro

 IPR002023; 2Fe-2S_Ferredox.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF01257; Complex1_24kDa 

SMART

  

PROSITE

 PS01099; COMPLEX1_24K 

PRINTS