CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010830
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclic AMP-responsive element-binding protein 1 
Protein Synonyms/Alias
 CREB-1; cAMP-responsive element-binding protein 1 
Gene Name
 Creb1 
Gene Synonyms/Alias
 Creb-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
136SRRPSYRKILNDLSSubiquitination[1]
330KTLIEELKALKDLYCubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. 
Sequence Annotation
 DOMAIN 101 160 KID.
 DOMAIN 283 341 bZIP.
 REGION 284 309 Basic motif (By similarity).
 REGION 311 332 Leucine-zipper (By similarity).
 MOD_RES 133 133 Phosphoserine; by CaMK1, CaMK2, CaMK4,
 MOD_RES 142 142 Phosphoserine; by CaMK2 (By similarity).
 MOD_RES 271 271 Phosphoserine; by HIPK2 (By similarity).
 CROSSLNK 285 285 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 304 304 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Activator; Alternative splicing; Complete proteome; Differentiation; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 60
GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD 120
SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG 180
QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV 240
VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 300
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D 341 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005719; C:nuclear euchromatin; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0035497; F:cAMP response element binding; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0071363; P:cellular response to growth factor stimulus; IDA:BHF-UCL.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0060430; P:lung saccule development; IMP:MGI.
 GO:0010944; P:negative regulation of transcription by competitive promoter binding; IEA:Compara.
 GO:0021983; P:pituitary gland development; IMP:MGI.
 GO:0045600; P:positive regulation of fat cell differentiation; IGI:UniProtKB.
 GO:0046887; P:positive regulation of hormone secretion; IMP:MGI.
 GO:0046889; P:positive regulation of lipid biosynthetic process; IGI:UniProtKB.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006468; P:protein phosphorylation; ISO:MGI.
 GO:0050821; P:protein stabilization; IMP:UniProtKB.
 GO:0008361; P:regulation of cell size; IGI:MGI.
 GO:0042493; P:response to drug; IDA:MGI.
 GO:0033363; P:secretory granule organization; IMP:MGI.
 GO:0060509; P:Type I pneumocyte differentiation; IMP:MGI. 
Interpro
 IPR004827; bZIP.
 IPR003102; Coactivator_CBP_pKID.
 IPR001630; Leuzip_CREB. 
Pfam
 PF00170; bZIP_1
 PF02173; pKID 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC
 PS50953; KID 
PRINTS
 PR00041; LEUZIPPRCREB.