CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002046
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Replication and transcription activator 
Protein Synonyms/Alias
 Rta; Immediate-early protein Rta 
Gene Name
 BRLF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) 
NCBI Taxa ID
 10377 
Lysine Modification
Position
Peptide
Type
References
19LRLTPEIKKQLGSLVsumoylation[1]
213FQTMVSSKTGHLTDDsumoylation[1]
426REGMFLPKPEAGSAIsumoylation[2]
446GREVCQPKRIRPFHPsumoylation[2]
517EETSQAVKALREMADsumoylation[1, 2]
530ADTVIPQKEEAAICGsumoylation[2]
Reference
 [1] Post-translational modification of Rta of Epstein-Barr virus by SUMO-1.
 Chang LK, Lee YH, Cheng TS, Hong YR, Lu PJ, Wang JJ, Wang WH, Kuo CW, Li SS, Liu ST.
 J Biol Chem. 2004 Sep 10;279(37):38803-12. [PMID: 15229220]
 [2] Epstein-Barr virus LF2 protein regulates viral replication by altering Rta subcellular localization.
 Heilmann AM, Calderwood MA, Johannsen E.
 J Virol. 2010 Oct;84(19):9920-31. [PMID: 20631124] 
Functional Description
 Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor. 
Sequence Annotation
  
Keyword
 Activator; Complete proteome; DNA-binding; Early protein; Host-virus interaction; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MRPKKDGLED FLRLTPEIKK QLGSLVSDYC NVLNKEFTAG SVEITLRSYK ICKAFINEAK 60
AHGREWGGLM ATLNICNFWA ILRNNRVRRR AENAGNDACS IACPIVMRYV LDHLIVVTDR 120
FFIQAPSNRV MIPATIGTAM YKLLKHSRVR AYTYSKVLGV DRAAIMASGK QVVEHLNRME 180
KEGLLSSKFK AFCKWVFTYP VLEEMFQTMV SSKTGHLTDD VKDVRALIKT LPRASYSSHA 240
GQRSYVSGVL PACLLSTKSK AVETPILVSG ADRMDEELMG NDGGASHTEA RYSESGQFHA 300
FTDELESLPS PTMPLKPGAQ SADCGDSSSS SSDSGNSDTE QSEREEARAE APRLRAPKSR 360
RTSRPNRGQT PCPSNAAEPE QPWIAAVHQE SDERPIFPHP SKPTFLPPVK RKKGLRDSRE 420
GMFLPKPEAG SAISDVFEGR EVCQPKRIRP FHPPGSPWAN RPLPASLAPT PTGPVHEPVG 480
SLTPAPVPQP LDPAPAVTPE ASHLLEDPDE ETSQAVKALR EMADTVIPQK EEAAICGQMD 540
LSHPPPRGHL DELTTTLESM TEDLNLDSPL TPELNEILDT FLNDECLLHA MHISTGLSIF 600
DTSLF 605 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR004998; Herpes_TAF50. 
Pfam
 PF03326; Herpes_TAF50 
SMART
  
PROSITE
  
PRINTS