| Tag | Content |
|---|
| CPLM ID | CPLM-003632 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proline/betaine transporter |
Protein Synonyms/Alias | Proline porter II; PPII |
Gene Name | proP |
Gene Synonyms/Alias | b4111; JW4072 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 22 | VTIIDDGKLRKAITA | acetylation | [1] | | 233 | AFQQHVDKLEQGDRE | acetylation | [1] | | 256 | SFKEIATKYWRSLLT | acetylation | [1] | | 487 | EIADLQAKRTRLVQQ | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. |
Sequence Annotation | |
Keyword | 3D-structure; Cell inner membrane; Cell membrane; Coiled coil; Complete proteome; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 500 AA |
Protein Sequence | MLKRKKVKPI TLRDVTIIDD GKLRKAITAA SLGNAMEWFD FGVYGFVAYA LGKVFFPGAD 60
PSVQMVAALA TFSVPFLIRP LGGLFFGMLG DKYGRQKILA ITIVIMSIST FCIGLIPSYD 120
TIGIWAPILL LICKMAQGFS VGGEYTGASI FVAEYSPDRK RGFMGSWLDF GSIAGFVLGA 180
GVVVLISTIV GEANFLDWGW RIPFFIALPL GIIGLYLRHA LEETPAFQQH VDKLEQGDRE 240
GLQDGPKVSF KEIATKYWRS LLTCIGLVIA TNVTYYMLLT YMPSYLSHNL HYSEDHGVLI 300
IIAIMIGMLF VQPVMGLLSD RFGRRPFVLL GSVALFVLAI PAFILINSNV IGLIFAGLLM 360
LAVILNCFTG VMASTLPAMF PTHIRYSALA AAFNISVLVA GLTPTLAAWL VESSQNLMMP 420
AYYLMVVAVV GLITGVTMKE TANRPLKGAT PAASDIQEAK EILVEHYDNI EQKIDDIDHE 480
IADLQAKRTR LVQQHPRIDE 500 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:EcoCyc. GO:0015653; F:glycine betaine:hydrogen symporter activity; IDA:EcoCyc. GO:0005297; F:hydrogen:proline symporter activity; IGI:EcoCyc. GO:0042538; P:hyperosmotic salinity response; IGI:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |