UniProt Accession

 ETS1_MOUSE; P27577; Q61403 

Genbank Protein ID

 M58482; X53953; X55787; BC010588 

Genbank Nucleotide ID

 AAA63299.1; CAA37904.1; CAA39310.1; AAH10588.1 

Protein Name

 Protein C-ets-1 

Protein Synonyms/Alias

 p54 

Gene Name

 Ets1 

Gene Synonyms/Alias

 Ets-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	KPTLTIIKTEKVDLE	sumoylation	[1]
58	ATFSGFTKEQQRLGI	ubiquitination	[2]
227	QTDYFAIKQEVLTPD	sumoylation	[1]
245	LGRASRGKLGGQDSF	acetylation	[3]

Reference

 [1] Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation.
 Ji Z, Degerny C, Vintonenko N, Deheuninck J, Foveau B, Leroy C, Coll J, Tulasne D, Baert JL, Fafeur V.
 Oncogene. 2007 Jan 18;26(3):395-406. [PMID: 16862185]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity). 

Sequence Annotation

 DOMAIN 51 136 PNT.
 DNA_BIND 335 415 ETS.
 REGION 130 243 Activation domain; required for
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 15 15 N6-acetyllysine; alternate (By
 MOD_RES 38 38 Phosphothreonine; by MAPK.
 MOD_RES 223 223 Phosphotyrosine (By similarity).
 MOD_RES 270 270 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine (By similarity).
 MOD_RES 305 305 N6-acetyllysine (By similarity).
 CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 227 227 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; DNA-binding; Immunity; Isopeptide bond; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0060055; P:angiogenesis involved in wound healing; IEA:Compara.
 GO:0048870; P:cell motility; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0060206; P:estrous cycle phase; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0021854; P:hypothalamus development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0030578; P:PML body organization; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
 GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
 GO:0010715; P:regulation of extracellular matrix disassembly; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0034616; P:response to laminar fluid shear stress; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR016311; Transform_prot_C-ets.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF02198; SAM_PNT 

SMART

 SM00413; ETS
 SM00251; SAM_PNT 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 

PRINTS

 PR00454; ETSDOMAIN.