UniProt Accession

 LIPT2_MOUSE; Q9D009; Q14C29; Q9CVA5 

Genbank Protein ID

 AK008917; AK011925; BC115472; BC115473 

Genbank Nucleotide ID

 BAB25967.1; BAB27920.1; AAI15473.1; AAI15474.1 

Protein Name

 Putative lipoyltransferase 2, mitochondrial 

Protein Synonyms/Alias

 Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase 

Gene Name

 Lipt2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	PGTLSGTKAGVLLVC	acetylation	[1]
43	PGTLSGTKAGVLLVC	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). 

Sequence Annotation

 REGION 85 92 Substrate binding (By similarity).
 REGION 154 156 Substrate binding (By similarity).
 REGION 167 169 Substrate binding (By similarity).
 ACT_SITE 185 185 Acyl-thioester intermediate (By  

Keyword

 Acyltransferase; Complete proteome; Ligase; Mitochondrion; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0033819; F:lipoyl(octanoyl) transferase activity; IEA:EC.
 GO:0016415; F:octanoyltransferase activity; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; IEA:InterPro.
 GO:0009107; P:lipoate biosynthetic process; IEA:InterPro. 

Interpro

 IPR004143; BPL_LipA_LipB.
 IPR000544; Octanoyltransferase. 

Pfam

 PF03099; BPL_LplA_LipB 

SMART

  

PROSITE

 PS01313; LIPB 

PRINTS